Introduction
NIAID Genomics Program
The NIAID has recognized the incredible potential of microbial genomic research and, in the last few years, has made a significant investment in genomic-related activities that provide comprehensive genomic, functional genomic, bioinformatics, and proteomic resources to the scientific community for basic and applied research to rapidly address the Institute’s mission and the Nation’s biodefense needs.
NIAID-supported genomic research programs include:
Structural Genomics
To build upon the objectives of the NIAID Genomics programs and address the Institute’s need to further expand the knowledge of the proteome, in September 2007 NIAID has launched a five-year initiative to establish large scale NIAID Structural Genomics Centers for Infectious Diseases that will apply state-of-the-art high-throughput structural biology technologies to experimentally characterize the three dimensional atomic structure of targeted proteins from pathogens in the NIAID Category A-C priority lists and organisms causing emerging and re-emerging infectious diseases.
The primary focus of the Structural Genomics Centers for Infectious Diseases are pathogen targets that are expected to have an important biological role and a potential impact on biomedical research, such as proteins involved in pathogenesis, proteins involved in antimicrobial/drug resistance; complexes with natural substrates, cofactors, receptors, drug candidates.
The Centers will also accept proposals for pathogen targets by external investigators, NIH and other Government agencies. A process to request the Centers to work of specific targets will shortly be made available here.
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