NIAID HIV and Emerging Infectious Diseases Program

TST Study

Study name

Correlation of the Precursor Frequency of CD4 + Effector Memory T cells with Induration measured in the Tuberculin Skin Test

Study number

06-I-0030

Goal of Study

The NIH is conducting a research study to investigate the human immune response to tuberculosis infection. Volunteers over 18 years old who have not been treated for tuberculosis are eligible to participate. The study is recruiting patients residing in the Washington DC, Maryland, and Virginia metropolitan area.

Study Regimen

The study will recruit 100 participants, 50 who are HIV-positive and 50 who are HIV-negative. All participants will have a skin test (known as PPD) for tuberculosis. Blood will be drawn. The study involves up to 6 visits. Volunteers will be compensated.

Eligibility Criteria

• You are age 18 or older
• You have adequate veins for blood draws
• You are willing to have a PPD test for tuberculosis
• You agree to have an HIV test, if you are HIV-negative
• You have normal blood counts
• You have never been treated for tuberculosis, and you do not have active tuberculosis
• You have never had a severe reaction to a PPD test
• You have not had a PPD test in the past 8 weeks

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