Arnold S. Kirshenbaum, M.D.

Adjunct Investigator

Dr. Kirshenbaum received his M.D. at Georgetown University in Washington, D.C. He did an internship and residency in pediatrics at the Naval Regional Medical Center affiliated with the University of California, San Francisco. Dr. Kirshenbaum trained in allergy and immunology during a fellowship at NIAID and is currently an adjunct investigator in the Laboratory of Allergic Diseases, NIAID. Dr. Kirshenbaum also practices adult and pediatric allergy and immunology in offices in Glen Burnie and Bowie, Maryland.

Major Areas of Research

• Mast cell growth and differentiation from progenitor cells
• Regulation of normal and neoplastic mast cell growth
• Systemic mast cell disorders

Memberships

• American Academy of Allergy, Asthma and Immunology (Fellow)
• American Association of Immunologists
• American Academy of Pediatrics, Maryland Chapter

Editorial Boards

• Journal of Leukocyte Biology

Selected Recent Publications

To view a complete listing, visit PubMed.

Chaves-Dias C, Hundley TR, Gilfillan AM, Kirshenbaum AS, Cunha-Melo JR, Metcalfe DD, Beaven MA. Induction of telomerase activity during development of human mast cells from peripheral blood CD34+ pluripotent cells: comparisons with tumor mast-cell lines. J Immunol. 2001. 166: 6647-6656.

Akin C, Jaffe ES, Raffeld M, Kirshenbaum AS, Daley T, Noel P, Metcalfe DD. An immunohistochemical study of the bone marrow lesions of systemic mastocytosis: expression of stem cell factor by lesional mast cells. Am J Clin Path. 2002. 118: 242-247.

Kirshenbaum AS, Akin C, Goff JP, Rottem M, Beaven MA, Rao VK, Metcalfe DD. Characterization of novel stem cell factor responsive human mast cells lines LAD 1 and 2 established from a patient with mast cells sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. Leuk Res. 2003. 27: 677-82.

Akin C, Brockow K, D'Ambrosio C, Kirshenbaum AS, Ma Y, Longley J, Metcalfe DD. Effects of the tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit. Exp Hematol. 2003. 31: 686-692.

Kirshenbaum AS, Akin C, Goff JP, Metcalfe DD. Thrombopoietin alone or in the presence of stem cell factor supports the growth of KIT(CD117)low/ MPL(CD110)+ human mast cells from hematopoietic progenitor cells. Exp Hematol. 2005. 33: 413-21.

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