Dean D. Metcalfe, M.D.

Chief, Laboratory of Allergic Diseases
Chief, Mast Cell Biology Section
Director, Allergy and Immunology Training Program

Dr. Metcalfe received his M.D. at the University of Tennessee and an M.S. in microbiology at the University of Michigan, where he also did a residency in internal medicine. Dr. Metcalfe then trained in allergy and immunology during a fellowship within NIAID, followed by training in rheumatology while a fellow in immunology at the Robert Brigham Hospital in Boston. He is a past president of the American Academy of Allergy, Asthma, and Immunology, and a past chair of the American Board of Allergy and Immunology.

Major Areas of Research

• Mast cell growth and differentiation and expression of biologic function
• Systemic mast cell disorders
• Adverse reactions to foods and additives
• Pathogenesis of asthma

Memberships

• Association of American Physicians
• American Academy of Allergy
• Asthma and Immunology (Fellow)
• American Association of Immunologists
• Clinical Immunology Society
• Collegium Internationale Allergologicum

Selected Recent Publications

To view a complete listing, visit PubMed.

Akin C, Fumo G, Yavuz AS, Lipsky PE, Neckers L, Metcalfe DD. A novel form of mastocytosis associated with transmembrane c-Kit mutation and response to imatinib. Blood. 2004. 103: 3222-3225.

Tkaczyk C, Horejsi V, Iwaki S, Draber P, Samelson LE, Nahm D-H, Metcalfe DD, Gilfillan AM. NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and FcεRI aggregation. Blood. 2004. 104:207-214.

Kulka M, Alexopoulou L, Flavell RA, Metcalfe DD. Activation of mast cells by double-stranded RNA: evidence for activation through toll-like receptor-3 (TLR-3). J Allergy Clin Immunol. 2004. 114: 174-182.

Hundley TR, Gilfillan AM, Tkaczyk C, Andrade MV, Metcalfe DD, Beaven MV. Kit and FcεRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells. Blood. 2004. 104: 2410-2417.

Taylor ML, Sehgal D, Raffeld M, Obiakor H, Akin C, Mage RG, Metcalfe DD. Demonstration that mast cells, T cells and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis. J Mol Diagn. 2004. 6: 335-342.

Swindle EJ, Metcalfe DD, Coleman JW. Rodent and human mast cells produce functionally significant intracellular reactive oxygen species, but not nitric oxide. J Biol Chem. 2004. 279: 48751-48759.

Kulka M, Metcalfe DD. High resolution tracking of cell division demonstrates differential effects of TH-1 and TH-2 cytokines on SCF-dependent human mast cell production in vitro: correlation with apoptosis and Kit expression. Blood. 2005. 105: 592-599.

Kirshenbaum AS, Akin C, Goff JP, Metcalfe DD. Thrombopoietin alone or in the presence of stem cell factor supports the growth of Kit (CD117) low/MPL (CD110)+ human mast cells from hematopoietic progenitors. Exp Hematol. 2005. 33: 413-421.

Kocabas C, Lipsky P, Metcalfe DD, Akin C. Analysis of the lineage relationship between mast cells and basophils employing the c-kit D816V mutation as a biologic marker. J Allergy Clin Immunol. 2005. 115(6): 1155-1161.

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