Sandip K. Datta, M.D.

Chief, Bacterial Pathogenesis Section

Tenure-Track Investigator

Sandip Datta received his M.D. from University of California, San Francisco, in 1996. He then completed his residency in internal medicine and fellowship in infectious diseases at University of California, San Diego (UCSD). Dr. Datta was appointed as assistant professor of medicine at UCSD in 2004. In February 2008, he joined the LCID as tenure-track chief of the newly formed Bacterial Pathogenesis Section.

Description of Research Program

The Bacterial Pathogenesis Section is a new section in the LCID, with the goal of understanding how host-bacteria interactions shape subsequent immune responses and using this knowledge to modulate and optimize host defense. As a new laboratory, we are still in the exciting process of formulating and shaping our specific projects and directions. We will use cellular, animal model, and patient-based studies to investigate the following areas:

Listeria monocytogenes (red) form actin tails (green) in mouse dendritic cells.

• Determinants of beneficial and pathologic immune responses to acute and chronic bacterial infections
• How bacteria shape T-cell differentiation
• How bacteria shape T-cell memory development
• Interplay between innate and adaptive immunity

Selected Publications

(To view a complete listing, search "Datta SK" in PubMed)

Del Pilar Jiménez-AM, Viriyakosol S, Walls L, Datta SK, Heinsbroek SEM, Brown G, Fierer J. Susceptibility to Coccidioides spp. in C57BL/6 Mice is associated with expression of a truncated splice variant of Dectin-1 (Clec7a). Genes Immun. Advance online publication 2008 Apr 17.

Datta SK, Okamoto S, Hayashi T, Shin SS, Mihajlov I, Fermin A, Guiney DG, Fierer J, Raz E. Vaccination with irradiated Listeria induces protective T cell immunity. Immunity. 2006 Jul;25(1):143-52.

Redecke V, Häcker H, Datta SK, Fermin A, Pitha PM, Broide DH, Raz E. Cutting edge: Activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol. 2004 Mar 1;172:2739-43.

Datta SK, Cho HJ, Takabayashi K, Horner AA, Raz E. Antigen-immunostimulatory oligonucleotide conjugates (AIC): mechanisms and applications. Immunol Rev. 2004 Jun;199:217-26.

Datta SK, Redecke V, Prilliman KR, Takabayashi K, Corr M, Tallant T, Didonato J, Dziarski R, Akira S, Schoenberger SP, Raz E. A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol. 2003 Apr 15;170(8):4102-10.

Horner AA, Datta SK, Takabayashi K, Belyakov IM, Hayashi T, Cinman N, Nguyen MD, Van Uden JH, Berzofsky JA, Richman DD, Raz E. Immunostimulatory DNA-based vaccines elicit multi-faceted immune responses against HIV at systemic and mucosal sites. J Immunol. 2001 Aug 1;167(3):1584-91.

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