Adriana Marques, M.D.
Chief, Clinical Studies Unit
Description of Research Program
The Clinical Studies Unit (CSU) was created in 1997. The CSU has as its main objective the development and conduct of clinical research in areas of interest to the Laboratory of Clinical Infectious Diseases and its senior staff. Clinical projects are underway that complement molecular studies.
Major Areas of Research
- Lyme disease
- Herpes simplex virus infections
- Shingles (herpes zoster virus) infections
- Autoimmune lymphoproliferative syndrome (ALPS)
- Chronic active Epstein-Barr virus disease (CAEBV)
Research Group Members
Koneti Rao, M.D.
Janet K. Dale, R.N., M.P.H.
Patricia Hohman, R.N.
Sonia Whittaker, L.P.N.
Nuralem Endale
Current Clinical Protocols
STARI
06-I-0207: Investigation of Southern Tick-Associated Rash Illness (STARI)
Lyme Disease
05-I-0219: Microarray Analysis of Erythema Migrans Lesions
02-I-0055: Evaluation, Treatment and Follow up of Patients with Lyme Disease
96-I-0052: A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients with Suspected Chronic Lyme Infection and Selected Control Populations
Herpes Zoster
99-I-0106: Trial of Varicella Vaccine for the Prevention of Herpes Zoster and Its Complications
Epstein-Barr Virus
02-I-0147: Genetic Studies of Chronic Active Epstein-Barr Virus Infection
Herpes Simplex Virus
97-I-0166: Polymorphism of the Herpes Simplex Virus Receptor
Autoimmune Lymphoproliferative Syndrome
02-I-0308: A Pilot Study of Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) for the Evaluation of the Autoimmune Lymphoproliferative Syndrome (ALPS) and ALPS-Associated Lymphoma
93-I-0063: Study of the Immunopathogenesis, Natural History, and Genetics of Autoimmune Lymphoproliferative Syndrome (ALPS) Associated with an Expansion of CD4-8-/TCR alpha/beta+ T Cells and Defective Lymphocyte Apoptosis
Selected Publications
Cassiani-Ingoni R, Cabral ES, Lunemann JD, Garza Z, Magnus T, Gelderblom H, Munson PJ, Marques A, Martin R. Borrelia burgdorferi induces TLR1 and TLR2 in human microglia and peripheral blood monocytes but differentially regulates HLA-Class II expression. J Neuropathol Exp Neurol. 2006 Jun;65(6):540-548.
Zhu, S, Hsu A, Vacek M, Lixin Z, Schaffer A, Dale J, Davis J, Fischer R, Straus S, Boruchov D, Saulsbury F, Lenardo M, Puck J. Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome. Human Genetics. 2006 Apr;119(3): 284-94.
Cabral ES, Gelderblom H, Hornung RL, Munson PJ, Martin R, Marques AR. Borrelia burgdorferi lipoprotein-mediated TLR2 stimulation causes the down-regulation of TLR5 in human monocytes. J Infect Dis. 2006 Mar 15;193(6):849-59.
Rao VK, Carrasquillo JA, Dale JK, Bacharach SL, Whatley M, Dugan F, Tretler J, Fleisher T, Puck JM, Wilson W, Jaffe ES, Avila N, Chen CC, Straus SE. Fluorodeoxyglucose positron emission tomography (FDG PET) for monitoring lymphadenopathy in the autoimmune lymphoproliferative syndrome (ALPS). A J Hematol. 2006; 81(2): 81-85.
Rao, VK, Straus SE. Causes and consequences of the autoimmune lymphoproliferative syndrome. Hematology. 2006 Feb;11(1):15-23.
Philipp MT, Wormser GP, Marques AR, Bittker S, Martin DS, Nowakowski J, Dally LG.A decline in C6 antibody titer occurs in successfully treated patients with culture-confirmed early localized or early disseminated Lyme Borreliosis. Clin Diagn Lab Immunol. 2005 Sep;12(9):1069-74.
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