Laboratory of Clinical Infectious Diseases

Steven M. Holland, M.D., Chief

The Laboratory of Clinical Infectious Diseases (LCID) conducts clinical and basic studies of important human infectious and immunologic diseases. Separate sections of the laboratory focus on mycobacterial, bacterial, viral, and fungal infections, as well as the acquired and congenital immune disorders that are associated with infection susceptibility and resistance. The program integrates clinical, cellular, and molecular investigation, including animal models.

The defining feature of the LCID is the focus on patients and their infections in order to develop a comprehensive understanding of natural history, pathogenesis, pathophysiology, and management of diseases.

Training of physicians and scientists is central to the LCID mission. We run the NIAID infectious diseases training program as well as the NIH Clinical Center infectious disease consultation service. The integration of these programs into the LCID is critical to the reciprocal educations of basic scientists and clinical fellows alike.

The major themes of the laboratory center on infections that are recurrent or chronic, as these provide insight into both host and pathogen. Current areas of emphasis include

• Mycobacterial infections (nontuberculous and tuberculous)
• Bacterial infections (Burkholderia species, new agents)
• Herpes virus infections (varicella zoster virus, Epstein-Barr virus, herpes simplex viruses)
• Fungal infections (aspergillosis, cryptococcosis, candidiasis)
• Immunodeficiencies causing syndromes of susceptibility to the above agents, such as chronic granulomatous disease (CGD), Job’s syndrome, defects of the IFNgamma/IL-12/23 pathway, autoimmune lymphoproliferative syndrome (ALPS), novel syndromes, chronic active Epstein-Barr virus (CAEBV), vaccinia virus

Office of the Chief

Steven M. Holland, M.D., Chief

Immunopathogenesis Section

Steven M. Holland, M.D.

Clinical Studies Unit

Adriana Marques, M.D.

Clinical Mycology Section

John E. Bennett, M.D.

Medical Virology Section

Jeffrey I. Cohen, M.D.
Stephen E. Straus, M.D.*
*deceased 

Molecular Microbiology Section

K.J. Kwon-Chung, Ph.D.

Tuberculosis Research Section

Clifton E. Barry, III, Ph.D.

Bacterial Pathogenesis Section

Sandip K. Datta, M.D.

Infectious Disease Fellowship Training Program

John E. Bennett, M.D., Director
Steven M. Holland, M.D., Co-Director

Infectious Disease Consultation Service

Juan Gea-Banacloche, M.D., Director

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