Laboratory of Cellular and Molecular Immunology

Ronald H. Schwartz, M.D., Ph.D., Chief 

The Laboratory of Cellular and Molecular Immunology studies the development, activation, tolerance, memory, differentiation, and death of thymus-derived (T) lymphocytes. Research projects currently focus on lineage commitment in the thymus, the role of danger and costimulatory signals in initiating an immune response, the molecular basis of costimulation, molecular and cellular aspects of T-cell anergy, the cloning of genes from thymic epithelial cells, dissection of in vivo models of CD4+ T-cell tolerance, and the cloning of genes involved in T-cell receptor activation-induced cell death. The laboratory offers educational training in immunology through tutorials and weekly journal clubs in addition to research training in techniques such as flow cytometry, gene cloning, and T-cell cloning. All research is carried out using mouse models.

Office of the Chief

Ronald H. Schwartz, M.D., Ph.D.

T-Cell Activation Section

Ronald H. Schwartz, M.D., Ph.D.

T-Cell Tolerance and Memory Section

Polly Matzinger, Ph.D.

T-Cell Development Section

B.J. Fowlkes, Ph.D.

T-Cell Biophysics Unit

Rajat Varma, Ph.D.

Thymic Molecular Development Unit

Moon G. Kim, Ph.D.

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