Laboratory of Immunology
William E. Paul, M.D., Chief
The Laboratory of Immunology (LI) is part of the Division of Intramural Research (DIR) of the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH) in Bethesda, MD. The major research activities of LI scientists concern the basic genetics, molecular biology, cell biology, and cellular immunology of the immune system. How dysregulation of the immune system results in autoimmune diseases and what strategies might be valuable for vaccine development are important topics of interest. Specific areas of current investigation include
- Early lymphocyte development
- T- and B-cell receptor gene rearrangement
- MHC molecule structure and function
- Antigen processing
- T-cell and cytokine receptor signal transduction
- Apoptotic cell death
- Regulation and activity of cytokines
- Mechanisms of cytotoxicity
- Control of autoimmune responses
Postdoctoral Training in the Laboratory of Immunology
Recent Research Contributions by Laboratory of Immunology Scientists
LI consists of nine independent laboratory groups (sections or units), each headed by a tenured or tenure-track scientist.
Biochemistry and Immunopharmacology Section
Bioorganic Chemistry Section
John K. Inman, Ph.D.
Cellular Immunology Section
Ethan M. Shevach, M.D.
Gene Targeting Unit
Hua Gu, Ph.D.
Immune Regulation Unit
William E. Paul, M.D.
Lymphocyte Biology Section
Ronald N. Germain, M.D., Ph.D.
Molecular Biology Section
David H. Margulies, M.D., Ph.D.
Molecular Development of the Immune System Section
Michael J. Lenardo, M.D.
Molecular Immunogenetics Section
Rose G. Mage, Ph.D.
Structural Immunobiology Unit
Tsan "Sam" Xiao, Ph.D.
Laboratory of Immunology Office
William E. Paul, M.D., Chief, wepaul@nih.gov
Ronald N. Germain, M.D., Ph.D., Deputy Chief, ronald_germain@nih.gov
Effie Hall, Secretary, ehall@niaid.nih.gov
Robin Burks, rburks@niaid.nih.gov
Maria Hessie, mhessie@niaid.nih.gov
Shirley Starnes, Editorial Assistant, sstarnes@niaid.nih.gov
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