Laboratory of Molecular Immunology
Philip M. Murphy, M.D., Chief
The Laboratory of Molecular Immunology (LMI) studies immune system function in health and disease and is especially interested in delineating mechanisms that control specific leukocyte movement. Research is conducted in the following areas:
- Molecular and cellular mechanisms of leukocyte trafficking in both innate and adaptive immunity with a focus on the chemokine family of chemoattractants
- G protein-coupled receptors of the immune system
- Mimics of chemotactic factors and their receptors in infectious agents, including HIV, herpesviruses, and poxviruses
- Structure and function of the mucosal immune system in the gut
- Basic properties of dendritic cells
- Molecular pathogenesis of complex infectious and immunologic/inflammatory diseases, including HIV/AIDS, West Nile virus infection, SARS, listeria infection, sepsis, atherosclerosis, Alzheimer's disease, and ischemia/reperfusion injury, with the goal of identifying novel therapeutic targets and vaccine strategies
- Genetic risk factors for complex immunologically mediated disease
Office of the Chief
Philip M. Murphy, M.D.
Inflammation Biology Section
Joshua Farber, M.D.
Molecular Signaling Section
Philip M. Murphy, M.D.
Mucosal Immunobiology Section
Brian Kelsall, M.D.
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