Laboratory of Viral Diseases
Bernard Moss, M.D., Ph.D., Chief
The Laboratory of Viral Diseases carries out investigations on the molecular biology of viruses, the interactions of viruses with host cells, the pathogenesis of viral diseases, and host defense mechanisms. The studies are designed to increase fundamental knowledge as well as to facilitate the development of new approaches to the prevention and treatment of disease. Current topics of basic research include viral entry into cells, regulation of gene expression, mechanisms of DNA replication, assembly and transport of viral proteins and particles, actions of viral growth factors and immune defense molecules, determinants of viral virulence, and viral targets of humoral and cellular immunity. Applied areas of research include development of recombinant expression vectors, candidate vaccines, and antiviral agents. These studies involve a wide range of DNA and RNA viruses including human immunodeficiency virus, poxviruses, herpesviruses, papillomaviruses, influenza virus, and poliovirus. The Laboratory is well equipped with an electron microscope, a confocal microscope, FACS machines, DNA sequencers, a DNA synthesizer, PCR machines, a BiaCore apparatus, ultracentrifuges, and other standard items. The members of the Laboratory are interactive and hold weekly seminars in which current research is presented and discussed.
Office of the Chief
Bernard Moss, M.D., Ph.D.
Jonathan W. Yewdell, M.D., Ph.D.
Jack R. Bennink, Ph.D.
Bernard Moss, M.D., Ph.D.
Thomas M. Kristie, Ph.D.
Alison McBride, Ph.D.
Edward A. Berger, Ph.D.
Ted C. Pierson, Ph.D.
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