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Bioinformatics Summit 2007

Date: May 8 and 9, 2007

Place: Courtyard Gaithersburg Washingtonian Center at Rio,
204 Boardwalk Place, Gaithersburg, MD 20878, (301) 527-9000

Background:

In the genomic era, both basic and clinical research rely heavily on database-supported computational-assisted bioinformatics. During the 2006 Bioinformatics Summit meeting, we reviewed many bioinformatics programs funded by the National Institute of Allergy and Infectious Diseases (NIAID), Division of Allergy, Immunology, and Transplantation (DAIT). We identified several areas of potential collaboration, synergy, and reusable resources within the different DAIT-funded bioinformatics and data management programs.

The main goals of the workshop in 2007 are to

  • Identify challenges of data reuse and data transformation and integration for hypothesis generation and secondary data analysis
  • Review alternative data management architectures from success stories and lessons learned and identify technological advances in promoting data integration
  • Report progress on dealing with challenges of data sharing and protecting patient privacy
  • Review efforts in building ontologies and data standards in the DAIT-funded research community

Agenda

To request audio files of the presentations, please contact Ashley Xia.

Day 1 May 8, 2007

8:30 am -
8:45 am
Opening remarks
Ms. Cheryl Kraft, Associate Director, Office of Biomedical Informatics, Division of Allergy, Immunology, and Transplantation, NIAID

Session I Reports on Ontologies and Data Standards in DAIT-Funded Projects

Chair: Dr. Mark Musen, Stanford

8:45 am -
9: 15 am
Representing Immunology in the GO: Ontology Development and Annotation
Dr. Alexander D. Diehl, Senior Scientific Curator, Mouse Genome Informatics, The Jackson Laboratory
9:15 am -
9:45 am
Data Standards for Flow Cytometry Data
Dr. Ryan Brinkman, Senior Scientist, Terry Fox Laboratory BC Cancer Research Centre, and Assistant Professor, Medical Genetics, UBC
9:45 am -
10:15 am
An Ontological Representation of Complex Immunological Networks
Dr. Lindsay Cowell, Assistant Professor, Department of Biostatistics and Bioinformatics, Duke University Laboratory of Computational Immunology, Center for Bioinformatics and Computational Biology
10: 15 am -
10:30 am
Break
10:30 am -
11:00 am
NCBC and Ontology Development
Dr. Mark Musen, Stanford Medical Informatics, Stanford University Medical Center
11:00 am -
11: 30 am
HLA: 1967 - 2007
Dr. Effie Petersdorf, Chair of the HLA Genetics Steering Committee, Fred Hutchinson Cancer Research Center Dr. Bjoern Peters, Epitope Database, La Jolla Institute for Allergy and Immunology
Dr. Richard H. Scheuermann, PI of the BISC contact, Director, Division of Translational Pathology, Professor, Department of Pathology, U.T. Southwestern Medical Center
11:30 am -
12:00 pm
Discussion
12:00 pm -
1:30 pm
Lunch

Session II Challenges in Data Sharing and Data Reusability

Chair: Dr. David Karp, University of Texas Southwestern Medical Center

1:30 pm -
2:00 pm
FDA's Critical Path and CDER's Office of Translational Sciences: Opportunities for Collaboration.
Dr. Stephen E. Wilson, Director, Division of biometrics III, CDER, FDA
2:00 pm -
2:30 pm
Computational Approaches for Patient Privacy Protection in Secondary Data Sharing
Dr. Bradley Malin, Assistant Professor of Biomedical Informatics, Vanderbilt University Medical Center, and Assistant Professor of Computer Science, Vanderbilt University
2:30 pm -
2:45 pm
Break
2:45 pm -
3:15 pm
Bioethics of Bioinformatics
Dr. David Karp, Co-PI of the BISC contract and Associate Professor and Chief, Rheumatic Diseases Division, U.T. Southwestern Medical Center
3:15 pm -
3:45 pm
Large-Scale Genetic Studies in the Framingham Heart Study
Dr. Anita L. DeStefano, Co-Director, Biostatistics Program, and Associate Professor of Biostatistics and Neurology, Boston University Schools of Public Health and Medicine
3:45 pm -
4:15 pm
Discussion

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Day 2 May 9, 2007

Session III Data Interoperability in NIAID Funded Projects

Chair: Ms. Cheryl Kraft, NIAID

8:00 am -
8:30 am
BISC Update on Data Interoperability through the Use of a Generic Experiment Object Model
Dr. Richard H. Scheuermann, PI of the BISC contract, and Director, Division of Translational Pathology, Professor, Department of Pathology, UT Southwestern Medical Center
8:30 am -
9:00 am
ITN Clinical Trials Management System
Mr. David Parrish, Director, Bioinformatics, Immune Tolerance Network
9:00 am -
9:30 am
DMID Bioinformatics Resources
Ms. Valentina Di Francesco, Bioinformatics Program Director, Division of Microbiology and Infectious Diseases, NIAID/NIH/DHHS
9:30 am -
10:00 am
DAIDS Enterprise System
Dr. Jonathan Kagan, Deputy Director, Program Development, Division of AIDS, NIAID
Mr. Hemant Virkar, Chief Architect, Digital Infuzion, Inc.
10:00 am -
10:15 am
Discussion
10:15 am -
10:30 am
Break

Session IV Technology Demonstration

Chair: Dr. Richard Scheuermann, University of Texas Southwestern Medical Center

10:30 am -
11:00 am
caBIG: Lessons Learned in the BRIDG Project
Dr. Douglas Fridsma, Assistant Professor of Medicine, University of Pittsburgh
11:00 am -
11:30 am
Second Order Semantic Enrichment and the Role of Wiki's for Professionals
Dr. Barend Mons, Associate Professor, Dept. of Medical Informatics, Leiden University Medical Center Rotterdam, the Netherlands
11:30 am -
12:00 pm
Discussion

DAIT Data Interoperability Steering Committee Meeting (DISC members only)

Chair: David Parrish, Director, Bioinformatics, Immune Tolerance Network

12:30 pm -
2:30 pm

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