NIAID Workshop: Development of Animal Models for Dengue

September 18, 2008 - Day One

8:30	NIAID Welcome Address, Catherine Laughlin, Ph.D. (NIAID)
8:35	NIAID Resources and Opportunities for Dengue Research, Cristina Cassetti, Ph.D. (NIAID)
Session I: Animal Models to Study Dengue Pathogenesis Chairs: Eva Harris and Rebeca Rico-Hesse
8:50	Human Pathogenesis and Mouse Models, Alan Rothman, M.D. (University of Massachusetts Medical School)
9:30	Dengue Disease and Immunity in Humanized Mice, Rebeca Rico-Hesse, Ph.D., MPH (Southwest Foundation for Biomedical Research)
10:00	Dengue Viral Pathogenesis and Immune Response in Humanized (RAG-hu) Mice, Ramesh Akkina, Ph.D. (Colorado State University)
10:30	Morning Break
11:00	The AG129 Mouse Model for Dengue Virus Infection and Disease, Eva Harris, Ph.D. (University of California, Berkeley)
11:30	A Mouse Model to Investigate T-cell Response to Dengue Virus, Sujan Shresta, Ph.D. (La Jolla Institute for Allergy and Immunology)
12:00	Discussion
12:30	Lunch Break
2:00	The Rhesus Macaque Model of DHF/DSS: How Close Are We to Human Disease?, Anna Durbin, M.D. (Johns Hopkins Bloomberg School of Public Health)
2:30	Passive Immunization in Monkeys Using Monoclonal Antibodies Against Dengue Virus, Ana Goncalvez, Ph.D. (Laboratory of Infectious Diseases, NIAID)
3:00	Yucatan Miniature Swine as an Immunogenicity and Infection Model for Dengue, Tim Burgess (Naval Medical Research Center)
3:30	Discussion
4:00	Afternoon Break
Session II: Animal Models to Evaluate Dengue Vaccines and Therapeutics Chairs: Anna Durbin and Stephen Whitehead
4:30	Evaluation of Attenuated Viruses in Mice and Monkeys, Stephen Whitehead, Ph.D. (Laboratory of Infectious Diseases, NIAID)
5:00	Dengue Vaccine, Monkey Animal Models and Sanof! Pasteur R&D Experience Thierry Decelle, DVM (Sanof! Pasteur)
5:30	Discussion
6:00	Adjourn

September 19, 2008 - Day Two

Session II, Continued: Animal Models to Evaluate Dengue Vaccines and Therapeutics Chairs: Anna Durbin and Steve Whitehead
8:30	Evaluation of Reproductive Toxicity of a Dengue Live-attenuated Vaccine Candidate in Mice, Sandra Giannini, Ph.D. (GlaxoSmithKline)
9:00	Dengue Vaccine Candidate Characterization Using Monkeys, Kenneth Eckels, Ph.D. (Walter Reed Army Institute of Research)
9:30	Evaluation of Anti-viral Drug Candidates in Dengue Mouse Models, Wouter Schul, Ph.D. (Novartis Institute for Tropical Diseases)
10:00	FDA Perspective, Lewis Markoff, M.D. (CBER, FDA)
10:15	Morning Break
Session III: Roundtable Discussion and Group Recommendations Chairs: Cristina Cassetti and John Roehrig
10:30	Summary of NHP models, Anna Durbin and Stephen Whitehead
11:00	Summary of Models for Vaccines, Stephen Whitehead and Anna Durbin
11:30	Summary of Pathogenesis, Scott Halstead and Alan Rothman
12:00	Pick Up Box Lunch
12:30	Summary of Murine Models, Eva Harris, Rebeca Rico-Hesse and Leonard Schultz
1:00	Summary of Models for Therapeutics Wouter Schul and Michael Diamond
1:30	Discussion
2:30	Adjourn