Anopheles gambiae Genome Sequencing Project
March 5, 2001
Statement of Anthony S. Fauci, M.D.
Director, National Institute of Allergy and Infectious Diseases
Today, a global network of researchers announced that they are collaborating in sequencing the genome of Anopheles gambiae, the mosquito responsible for most cases of malaria in Africa. The National Institute of Allergy and Infectious Diseases (NIAID) applauds the efforts of the network and their goal of obtaining sequence data by the end of the year.
This information, together with the knowledge gained from the sequences of malaria parasites and the human genome, will provide researchers with a wealth of genomic data necessary for understanding this complex disease. (See the communique.)
The need for a multifaceted commitment to fight malaria and develop new and improved treatments, diagnostics and vaccines has never been greater. According to the World Health Organization, an estimated 300 to 500 million cases of malaria occur annually; in 1999, an estimated 1.1 million deaths were attributed to malaria, most of which occurred in children under the age of 5. Malaria is a public health threat in more than 90 countries, where 40 percent of the world's population lives. Because of the enormity of this problem, NIAID has made malaria research a central focus of our scientific portfolio and supports a comprehensive research program, which includes basic, field-based and clinical research.
Malaria is caused by a single-celled parasite that is spread to humans by mosquitoes. The control of malaria continues to be a challenge because of the dual problems of increased rates of insecticide resistance in mosquitoes and increased rates of drug resistance in the malaria parasites. Reducing disease transmission by mosquito control has been a mainstay of regional and global malaria control programs. The insecticide DDT was once a powerful tool in global efforts to eradicate malaria. With the development of DDT-resistant mosquitoes, new tools are needed to control this disease. An improved understanding of the basic biology of mosquitoes and their genomes will contribute to our ability to understand and monitor insecticide resistance, develop new insecticides, and ultimately help control the malaria pandemic.
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