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Regional Centers of Excellence for Biodefense and Emerging Infectious Diseases (RCEs)

Publications

2006

Region I: New England RCE; Harvard Medical School

Pelish HE et al. Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol. 2006 Jan;2(1):39-46. Epub 2005 Nov 20. PMID: 16408091 [PubMed - indexed for MEDLINE]

Region II: Northeast Biodefense Center, NYSDOH

Li Z. et al. The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus. Immunity. 2006 Apr;24(4):393-403.
PMID: 16618598 [PubMed - in process]

Kang YS. et al.
A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q. Cell. 2006 Apr 7;125(1):47-58. PMID: 16615889 [PubMed - in process]

Domingo C. et al. Use of a short fragment of the C-terminal E gene for detection and characterization of two new lineages of dengue virus 1 in India. J Clin Microbiol. 2006 Apr;44(4):1519-29. PMID: 16597885 [PubMed - in process]

Boscardin SB. et al. Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses. J Exp Med. 2006 Mar 20;203(3):599-606. Epub 2006 Feb 27. PMID: 16505139 [PubMed - indexed for MEDLINE]

McClelland EE. et al. Estimating the relative contributions of virulence factors for pathogenic microbes. Infect Immun. 2006 Mar;74(3):1500-4.
PMID: 16495520 [PubMed - in process]

Prakash A. et al. Regulation of IRF7 through cell type-specific protein stability. Biochem Biophys Res Commun. 2006 Mar 31;342(1):50-6. Epub 2006 Feb 3. PMID: 16472772 [PubMed - indexed for MEDLINE]

Ely KH et al. Memory T cell populations in the lung airways are maintained by continual recruitment. J Immunol. 2006 Jan 1;176(1):537-43. PMID: 16365448 [PubMed - indexed for MEDLINE]

Region III

Katz J. et al. Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS.
Infect Immun. 2006 May;74(5):2809-16.
PMID: 16622218 [PubMed - in process]

Raises KW et al. Importance of nitric oxide synthase in the control of infection by Bacillus anthracis.
Infect Immun. 2006 Apr;74(4):2268-76.
PMID: 16552057 [PubMed - in process]

Zhu Z et al. Development of human monoclonal antibodies against diseases caused by emerging and biodefense-related viruses.
Expert Rev Anti Infect Ther. 2006 Feb;4(1):57-66. Review.
PMID: 16441209 [PubMed - indexed for MEDLINE]

Bossart KN et al. Developments towards effective treatments for Nipah and Hendra virus infection.
Expert Rev Anti Infect Ther. 2006 Feb;4(1):43-55. Review.
PMID: 16441208 [PubMed - indexed for MEDLINE]

Davis CW et al. West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection.
J Virol. 2006 Feb;80(3):1290-301.
PMID: 16415006 [PubMed - indexed for MEDLINE]

Zhu Z et al. Potent neutralization of Hendra and Nipah viruses by human monoclonal antibodies.
J Virol. 2006 Jan;80(2):891-9.
PMID: 16378991 [PubMed - indexed for MEDLINE]

Region IV

Prichard MN. et al. Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.
Infect Immun 2006 Apr, 74(4):2063-71
PMID: 16569849 [PubMed - in process]

Dillion S. et al.
Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.
J Clin Invest 2006 Apr:116(4):916-28
PMID: 16543948 [PubMed - in process]

Liu C. et al.
Longitudinal analysis of T-cell receptor variable beta chain repertoire in patients with acute graft-versus-host disease after allogeneic stem cell transplantation.
Biol Blood Marrow Transplant 2006 Mar, 12(3):335-45
PMID: 16503503 [PubMed - in process]

Querec T.
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity.
J Exp Med 2006 Feb 20;203(2):413-24, Epub 2006 Feb. 6
PMID: 16461338 [PubMed - indexed for MEDLINE]

Doyle J et al.
Two domains that control prefusion stability and transport competence of the measles virus fusion protein.
J Virol. 2006 Feb;80(3):1524-36.
PMID: 16415028 [PubMed - indexed for MEDLINE]

Gerdon AE et al.
Epitope mapping of the protective antigen of B. Anthracis by using nanoclusters presenting conformational peptide epitopes.
Angew Chem Int Ed Engl. 2006 Jan 16;45(4):594-8. No abstract available.
PMID: 16355420 [PubMed - in process]

Region V

Rajashekara G et al.
Attenuated bioluminescent Brucella melitensis mutants GR019 (virB4), GR024 (galE), and GR026 (BMEI1090-BMEI1091) confer protection in mice.
Infect Immun. 2006 May;74(5):2925-36.
PMID: 16622231 [PubMed - in process]

Watanabe S. et al.
Functional mapping of the nucleoprotein of Ebola virus.
J Virol. 2006 Apr;80(8):3743-51.
PMID: 16571791 [PubMed - indexed for MEDLINE]

Marraffini LA et al.
Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria.
Microbiol Mol Biol Rev. 2006 Mar;70(1):192-221. Review.
PMID: 16524923 [PubMed - indexed for MEDLINE]

Kim HY et al.
Regioselective synthesis of N-beta-hydroxyethylaziridines by the ring-opening reaction of epoxides with aziridine generated in situ.
Org Lett. 2006 Mar 16;8(6):1085-7.
PMID: 16524274 [PubMed - in process]

Hanson JF et al.
Neutralizing antibodies and persistence of immunity following anthrax vaccination.
Clin Vaccine Immunol. 2006 Feb;13(2):208-13.
PMID: 16467327 [PubMed - indexed for MEDLINE]

Skaar EP et al.
Bacillus anthracis IsdG, a heme-degrading monooxygenase.
J Bacteriol. 2006 Feb;188(3):1071-80.
PMID: 16428411 [PubMed - indexed for MEDLINE]

Region VI

Pammit MA et al.
Intranasal vaccination with a defined attenuated Francisella novicida strain induces gamma interferon-dependent antibody-mediated protection against tularemia.
Infect Immun 2006 Apr;74,
PMID: 16552035 [PubMed - in process]

Ikegami T. et al.
Rescue of infectious rift valley fever virus entirely from cDNA, analysis of virus lacking the NSs gene, and expression of a foreign gene.
J. Virol 2006 Mar;80(6):2933-40.
PMID: 16501102 [PubMed - indexed for MEDLINE]

Paessler S. et al.
Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses.
J Virol 2006 Mar,80(6):2784-96
PMID: 16501087 [PubMed - indexed for MEDLINE]

Region VII

Lee JS. et al.
Mucosal immunization with surface-displayed severe acute respiratory syndrome coronavirus spike protein on Lactobacillus casei induces neutralizing antibodies in mice.
J Virol. 2006 Apr;80(8):4079-87.
PMID: 16571824 [PubMed - indexed for MEDLINE]

Liszewski MK et al.
Structure and regulatory profile of the monkeypox inhibitor of complement: comparison to homologs in vaccinia and variola and evidence for dimer formation.
J Immunol. 2006 Mar 15;176(6):3725-34.
PMID: 16517741 [PubMed - indexed for MEDLINE]

Felts RL. et al.
Crystallization of a newly discovered histidine acid phosphatase from Francisella tularensis.
Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Jan 1;62(Pt 1):32-5. Epub 2005 Dec 16.
PMID: 16511256 [PubMed - in process]

Xu D et al.
The latent membrane protein 1 of Epstein-Barr virus (EBV) primes EBV latency cells for type I interferon production.
J Biol Chem. 2006 Apr 7;281(14):9163-9. Epub 2006 Feb 9.
PMID: 16469740 [PubMed - in process]

Pelosof LC et al.
Co-ordinate but disproportionate activation of apoptotic, regenerative and inflammatory pathways characterizes the liver response to acute amebic infection.
Cell Microbiol. 2006 Mar;8(3):508-22.
PMID: 16469061 [PubMed - indexed for MEDLINE]

Ludlam CA et al.
Clinical perspectives of emerging pathogens in bleeding disorders.
Lancet. 2006 Jan 21;367(9506):252-61. Review.
PMID: 16427495 [PubMed - indexed for MEDLINE]

Chung KM et al.
Antibodies against West Nile Virus nonstructural protein NS1 prevent lethal infection through Fc gamma receptor-dependent and -independent mechanisms.
J Virol. 2006 Feb;80(3):1340-51.
PMID: 16415011 [PubMed - indexed for MEDLINE]

Region VIII

Region IX

Arndt JW. et al.
Structure of botulinum neurotoxin type D light chain at 1.65 A resolution: repercussions for VAMP-2 substrate specificity.
Biochemistry 2006 Mar 14;45(10):3255-62
PMID: 16519520 [PubMed - indexed for MEDLINE]

Region X

Ferens Wa et al.
Intestinal Shiga toxin-producing Escherichia coli bacteria mitigate bovine leukemia virus infection in experimentally infected sheep.
Infect Immun 2006 May;74(5):2906-16
PMID: 16622229 [PubMed- in process]

Dobbin HS. et al.b
The Escherichia coli O157 flagellar regulatory gene flhC and not the flagellin gene fliC impacts colonization of cattle.
Infect Immun 2006 May;74(5):2894-905
PMID: 16622228 [PubMed- in process]

Reibeil R et al.
Characterization of late acyltransferase genes of Yersinia pestis and their role in temperature-dependent lipid A variation.
J Bacteriol 2006 Feb;188(4):1381-8
PMID: 16452420 [PubMed - indexed for MEDLINE]

Bylund J et al.
Exopolysaccharides from Burkholderia cenocepacia inhibit neutrophil chemotaxis and scavenge reactive oxygen species.
J Biol Chem. 2006 Feb 3;281(5):2526-32. Epub 2005 Nov 29.
PMID: 16316987 [PubMed - in process]

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RCE Program Evaluation: Report on the First Five Years (PDF - March 11, 2008)

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RCE Program Evaluation: Report on the First Five Years (PDF - March 11, 2008)