New Humanized Rodent Model Workshop
September 26, 2007
Rockville, MD
It has long been recognized that a small animal model with a reconstituted human immune system would be extremely useful in the study of HIV/AIDS pathogenesis and for the evaluation of vaccine and therapeutic strategies to combat this disease. By early 2007, a number of reports on rodent models with a humanized immune system capable of being infected by and responding to HIV were published.
The New Humanized Rodent Model Workshop, organized by the Division of AIDS, National Institute Allergy and Infection Diseases, NIH, was held for the purpose of bringing together key model developers and potential users. The meeting included a discussion about the current status of the models, future plans, as well as potential use of the models for addressing critical issues in basic immune response studies, pathogenesis, therapeutics, vaccines and microbicides development.
List of questions addressed by the speakers and panel
Presentation Materials
Session 1
Chair: Tony Conley
| Speaker |
Title |
| Dan Littman |
Overview, where we are, how we got here |
| Oliver Keppler |
Block-by-block humanization: Advances and challenges in the immunocompetent multi-transgenic rat model of HIV-1 infection |
Session 2
Chair: Fulvia Veronese
| Speaker |
Title |
| Ramesh Akkina |
Modeling HIV and Dengue viral pathogenesis and therapies in humanized Rag2-/-gamma c-/- (RAG-hu) mouse mode |
| Jeremy Luban |
HIV-1 infection in CD34+ cord blood cell-transplanted Rag2-/-{gamma}c-/- mice |
Session 3
Chair: Paul Black
| Speaker |
Title |
| Lishan Su |
Modeling human immunobiology and HIV-1 pathogenesis in the humanized Rag-gammaC- DKO mouse |
| Roberto Speck |
The humanized mouse model for studying HIV infection: more tricky than expected |
Session 4
Chair: Jim Turpin
| Speaker |
Title |
| J. Victor Garcia Martinez |
BLT mice: a stable, robust and flexible platform for the comprehensive study of HIV/AIDS |
| Harris Goldstein |
Summary of recommendations of panel, where we are going, and how we get there |
If you would like to receive a copy of any of the presentations, please contact Janet Young at jyoung@niaid.nih.gov.
back to top