Requests for Use of Nonhuman Primates at Simian Vaccine Evaluation Units
Simian Vaccine Evaluation Units evaluate promising SIV and HIV vaccines in nonhuman primates in order to accelerate HIV vaccine development.
The Simian Vaccine Evaluation Units (SVEUs) provide nonhuman primates for evaluation of candidate SIV or HIV vaccines. Proposals from investigators for vaccine studies (see the guidelines for submission of proposals) are evaluated by NIAID, and approved studies are conducted at one of the three SVEU contract sites. Studies conducted at SVEUs are collaborative. The vaccine investigator will be expected to participate, with the SVEU Principal Investigator and the SVEU Project Officer, in the design of the study and in discussion and evaluation of data and results. The SVEU contractor will immunize nonhuman primates with the candidate vaccine and, together with the Primate Immunology Laboratory, can evaluate humoral and cellular immune responses. The SVEU can also challenge the animals with virus, determine whether or not the animals become infected, conduct assays to determine the levels of replicating virus, and evaluate disease outcomes. The SVEUs conduct several types of studies: (I) preliminary studies on new vaccines, (II) efficacy studies with vaccines that have already demonstrated promise, (III) studies with passively administered products, and (IV) in vivo titration of virus challenge stocks. SVEUs may also evaluate the immunogenicity and safety of candidate HIV vaccines (or SIV vaccines that parallel HIV vaccines in approach) in support of Phase I human clinical trials. In addition, the SVEUs can conduct comparative studies on vaccines and/or adjuvants from multiple sources.
Current Simian Vaccine Evaluation Unit Contractors
Advanced BioScience Laboratories
Kensington, MD
P.I.: Dr. Phil Markham
Southern Research Institute
Frederick, MD
P.I.: Dr. Mark Lewis
University of Washington
Seattle, WA
P.I.: Dr. William Morton
Current Primate Immunology Laboratory Contractors
Cellular Immune Assays:
Beth Israel Hospital
Boston, MA
P.I.: Dr. Norman Letvin |
Virus Neutralization Assays:
Duke University
Durham, NC
P.I.: Dr. David Montefiori |
Contact
Dr. Nancy Miller
Phone: 301-435-3753
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