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Biodefense

Biodefense and Emerging Infectious Diseases Research Opportunities PA03-080
Exploratory/Developmental Grants (R21s)

FY 2004 Awards

InstitutionPI NameTitle
Baylor College of Medicine George WeinstockFrancisella genomics
Benaroya Research Institute at Virginia Mason Gerald Nepom MHC tetramers for epitopes of B anthracis PA
Brigham and Women's Hospital Lynn Bry Protective role of cross-reactive anti-enteric antibody
Burnham Institute Kristina VuoriMechanisms of anti-phagocytosis by Yersinia pestis
Children's Hospital (Boston)Nicholas MantisGastrointestinal immunity Ricin
Cleveland Clinic Lerner Col/Med-CWRUAndrew LarnerThe effects of interferon on anthrax toxicity
Dartmouth CollegeSurachai SupattaponeSpecies susceptibility assay for chronic wasting disease
Duke UniversityRichard FrothinghamAlternative endpoints for plague challenge models
Duke UniversityJohn HollingsworthGenetic susceptibility to F. tularensis
Eastern Virginia Medical School Yuping Deng The response to influenza: aging & vaccine efficacy
Emory UniversityRichard CompansDevelopment of VLP vaccines for SARS prevention
Georgetown UniversityRadkarkrishnan PadmanabhanDengue & west nile viral protease inhibitors
Georgetown UniversityMitchell Jung Role of PARP-1 in salmonella pathogenesis
Georgia State UniversityMargo BrintonOas-1 gene transgenic mice for WNV research
Hauptman-Woodward Medical Research Institute L. Wayne SchultzStructural studies of SARS & MHV replicase proteins
Henry M. Jackson FDN for the ADV MIL/MED Anthony MaurelliMetabolic modeling of invasive bacteria & HeLa Cytosol
Iowa State UniversityJames RothNipah virus marker vaccine & companion diagnostic test
Johns Hopkins University Ernst SpannhakeBronchial epithelial cell costimulation of CD4+ T cells
Johns Hopkins UniversityRobert Gilman Transmission dynamics of cryptosporidium sp.
Kansas State University George StewartFunction of the B. anthracis spore carbohydrate
La Jolla Institute for Allergy/ImmunologyChristopher BenedictActivation of innate antiviral defenses by LTbetaR
Massachusetts General HospitalMarcia GoldbergAutotransporter periplasmic chaperones in Shigella
Massachusetts General Hospital Indira Kudva E. coli 0157:H7 genes induced during human infection
Mayo Clinic College of Medicine, Rochester Marilia CascalhoMutable vaccine for biodefense
Montana State University, BozemanMarcella McClureA bioinformatic approach to inferring protein contracts
National Research Council of Canada Wangxue ChenMouse model of oral infection with virulent Francisella
New England Medical Center HospitalsJenifer CoburnVascular tropism of Borrelia burgdorferi
New York University School of Medicine Yvette WeinrauchInteraction of enteroinvasive pathogens with neutrophils
North Carolina State University, RaleighBarbara Sherry Poxvirus adverse effects on cardiac cells & the heart
Northeastern University Kim LewisNovel methods for discovery of antimicrobials
Northeastern UniverisityKim Lewis Biodefense therapeutics from uncultured microorganisms
Northern Arizona UniversityFernando Monroy Innate intestinal responses in murine toxoplasmosis
Oregon Health & Science University David JohnsonHantavirus vaccines based on nonreplicating adenoviruses
Oregon Health & Science University Jay NelsonThe role of Src kinase in west nile virus replication
Oregon Health & Science UniversityJorge CrosaIron uptake & virulence of Burkholderia pseudomallei
Oregon Health & Science UniversityEric Barklis Analysis of sin nombre virus inhibition in lung cells
Oregon State University Dennis Hruby Variola virus G1L: an antiviral drug target
Public Health Research InstituteGilla KaplanCytokines in pathogenesis of anthrax infection
Rice UniversityMichael DeemModeling of multivalent vaccination for variable viruses
Rutgers the State University of New Jersery, New BrunswickNilgun TumerMechanism of action of ricin A chain
San Diego State UniversityAnca SegallInhibitors of poxvirus holliday junction resolvase
Scripps Research InstituteLisa CraigStructure & assembly of type IVb Pili
Sidney Kimmel Cancer CenterMichael McClelland?
Southern Research InstituteAshish PathakNew adjuvant technologies for a marburg virus vaccine
SRI InternationalSeajin OhTransdermal vaccine delivery platform technology
St. Jude Children's Research CenterRobert WebsterCombination chemotherapy for pandemic influenza
St. Jude Children's Research CenterStephen White Development of DHPS as a bioterrorism therapeutic target
St. Louis UniversityRobert BullerStudy of monkeypox virus in rodents
St. Louis UniversityDaniel HoftVaccine induced mucosal protection against TB infection
Stanford University Ronald Davis Charge-based pathogen DNA detection
State University of New York at BuffaloEdward Niles Novel inhibitors of poxvirus replication
Texas A&M University Health Sciences CenterGeorge Davis Function of CMG-2, an anthrax toxin receptor
Texas A&M University Health Sciences CenterYi XuCell wall protein in B. anthracis pathogenesis
Thomas Jefferson University Michael RootStructure of SARS coronavirus spike glycoprotein
Thomas Jefferson University Phyllis FlomenbergHuman T cell responses to vaccinia vaccine
Trudeau Institute, Inc. Robert North M. bovis as a potentially more virulent MDR pathogen
Tufts UniversityAndrew BohmMolecular basis for inhibition of edema factor
Tufts UniversityMatthew Waldor Role of Hfq in Vibrio cholerae virulence
Tufts University, BostonNaomi BalabanQuorum sensing & staphylococcus aureus pathogenesis
Tufts University, Boston Giovanni WidmerGenetic transformation of Cryptosporidium parvum
University of Alabama at Birmingham David Pritchard B. anthracis peptidoglycan deacatylase as a drug target
University of Alabama at BirminghamJohn BarrInvestigation of Bunyamwera bunyavirus gene expression
University of California, Davis Paulo VerardiSMART virus vectors with built-in safety mechanism
University of California, Los AngelesBenhur Lee A reverse genetic system for the study of Nipah virus
University of California, San DiegoEthan BierGenetic analysis of bacterial toxins in drosophila
University of California, San DiegoMaurizio ZanettiConformationally-constrained PA anthrax vaccine
University of California, San Diego Robert RickardC3d-PA: efficacy & cellular basis as an anthrax vaccine
University of California, Santa BarbaraMichael MahanEpigenetic control of bacterial virulence
University of ChicagoDavid WhiteAntigen delivery using novel Fc receptor ligands
University of GeorgiaJulie Coffield Indentification of Botulinum toxin membrane targets
University of HoustonSteven Blanke C. jejuni cytolethal distending toxin cell interactions
University of Iowa Gregory GrayPopulation-based surveillance for zoonotic influenza A
University of Kentucky Susan StraleySurface proteins in pneumonic plague
University of Maryland Baltimore Prof. SchoolAlexander SulakvelidzeGenetic clustering & virulence of Y. pestis strains
University of Michigan at Ann Arbor Maria Diakonova Role of adaptor protein in infectious diseases
University of Minnesota, Twin CitiesMitchell Abrahamsen Purine salvage in Cryptosporidium parvum
University of Montana Jack NunbergStructure-function of junin virus envelope glycoproteins
University of Nebraska, Lincoln Andrew BensonGenome biology of Francisella tularensis populations
University of North Carolina, Chapel Hill Thomas KawulaMolecular basis of Francisella virulence and immunity
University of North Carolina, Chapel Hill Janne Cannon Antigenic variation in F. tularensis
University of North Carolina, Chapel Hill Aravinda De Silva Interactions between dengue 3 & human dendritic cells
University of PennsylvaniaDieter SchifferliFunction & immunogenicity of Yersinia pestis fimbriae
University of PennsylvaniaRonald HartyEbola virus VP40-host interactions in vivo
University of Pittsburgh at Pittsburgh Saleem Khan Genomics/proteomics of enterotoxin B producing S. aureus
University of Pittsburgh at Pittsburgh Saleem Khan Plasmid pX02 replication in B. anthracis
University of Tennessee, KnoxvilleMark SangsterInduction of influenza virus-specific memory B cells
University of Tennessee Health Sciences CenterGeorge HilliardProtein expression in strains of F. tularensis
University of Washington Kelly Hughes Flagellar phase variation in salmonella
University of Wisconsin, MadisonEric JohnsonDevelopment of genetic tools for Clostridium botulinum
Vanderbilt University Michael RockVaccinia virus-specific T cell phenotypes
Vanderbilt University Richard PeekInhibition of pathogen-induced NGkB-mediated inflammation
Vanderbilt University GN GreenIntracellular inhibitors of botulinum neurotoxins
Virginia Polytechnic Institute and St. Univ.David Popham Spore peptidoglycan degradation in B. anthracis
Virginia Polytechnic Institute and St. Univ.Yongquin HeGene expression in brucella-infected macrophages
Wadsworth Center David WentworthDiscovery of a novel promoter in pathogenic influenza
Wadsworth Center Kathleen McDonoughDifferential gene expression in Yersinia pestis
Wadsworth Center Paul MastersSARS coronavirus reverse genetics & pathogenesis
Wake Forest University Health Sciences Kevin High Brucella, aging & role of IL-17 in host defense
Weill Medical College of Cornell UniversityJohn HoAntigen capture assays for rabid tuberculosis diagnosis
Weill Medical College of Cornell UniversityRichard GransteinVaccine development: purinergic agonists as adjuvants
Weill Medical College of Cornell UniversityJulie BoyerGenetic passive immunotherapy for Shiga toxin

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