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Biodefense

Biodefense and Emerging Infectious Diseases Research Opportunities PA03-080 -- Research Project Awards (R01s)

FY 2005

InstitutionPI NameTitle
Apath, LLC Paul Olivo Therapeutics for Ebola virus
Arizona State UniversityRoy Curtis, III Salmonella anti-influenza DNA & antigen delivery vaccine
Arizona State University Bertram JacobsDevelopment of a post-exposure vaccine for smallpox
Baylor College of MedicineBiao Zheng Fc Receptor Signaling in Vaccine Design for the Elderly
Blood Center of Southeastern WisconsinJack GorskiEpitope Selection by HLA-DR
Brigham and Women's HospitalMichael BrennerCD1d-Restricted T Cell Self-Antigens and Infection
Brigham and Women's HospitalMichael BrennerT Lymphocyte Recognition
Brigham and Women's HospitalJohn IacominiRegulation of Anti-Carbohydrate Natural Antibodies
Burnham InstituteAndrei OstermanTargeting cofactor biosynthesis in biodefense pathogens
Children's Research Hospital and Research Center at Oakland Donald Reason Human monoclonal panel mimicking anthrax immune globulin
Children's Hospital Medical Center (Cincinnati) Xi Jiang Norwalk-like Viruses and Their Receptors
Colorado State University - Fort CollinsJeffrey WiluszVirus-Mosquito mRNA Stability
Cornell University - IthicaDavid RussellDevelopment of a Novel Strategy of Adjuvant Discovery
Drexel University College of MedicinePeter KatsikisDendritic Cell Regulation of CD8+ T Cell Responses
Emory University Jan Mead Immunodominant Targets of CMI to Cryptosporidium
Emory University Robert Mittler CD137 Signals in DV During AG-Priming Induces Tolerance
Florida State University Timothy Cross Correlations: Structure-Dynamics-Functions in Channels
Fred Hutchinson Cancer Research Center Roland Strong Microbial Siderophore-Specific Innate Immunity Responses
Harvard University Medical School Sean Whelan RNA processing in non-segmented minus-strand RNA viruses
Indiana University - Purdue University at Indianapolis Randy BrutkiewiczCDI Molecules and NKT Cells in Host Defense
Infectious Disease Research Institute Steven Reed Human T Cell Antigens of Mycobacterium tuberculosis
Johns Hopkins University Vernon Carruthers Microneme Function in Toxoplasma
La Jolla Institute for Allergy/ImmunologyHilde CheroutreSelective Instructions for Memory Precursor T Cells
La Jolla Institute for Allergy/ImmunologyShane CrottyHumoral Immunity to Vaccinia Virus
La Jolla Institute for Allergy/ImmunologyDavid LoGene expression in Peyer's Patch FAE development
Massachusetts General Hospital Marcia Goldberg Mechanism and function of unipolarity of Shigella IcsA
Massachusetts General Hospital Christian LeguernModulation of T Lymphocyte Regulation
Maxthera, Inc. Ania KnapBroad Spectrum Agents Against Cat A Bacterial Pathogens
Medical College of GeorgiaAndrew Mellor IDO Dependent T Cell Suppression
Medical College of Ohio at Toledo Dorothea Sawicki Alphavirus Minus Strand RNA Synthesis and RNase L
Medical College of Ohio at Toledo Isabel NovellaDeterminants of RNA virus evolution
Medical College of WisconsinNita SalzmanRegulation Paneth Cell Defensins by Bacterial Infection
Medical College of WisconsinPaula TraktmanVaccinia Encoded Kinases and Phosphatases
Montana State University (Bozeman) David Pascual Mucosal Immunity Elicited by Salmonella Vaccine Delivery
Mount Sinai School of Medicine of NYU Christopher Basler Ebola VP35 Interferon-Antagonist: Mechanism and Signif
Nanotherapeutics, Inc. James Talton Inhaled Aminoglycoside Formula for Plague and Tularemia
New England Medical Center HospitalsCheleste Thorpe Shiga Toxin & Ricin: Mechanisms of Ribotoxic Stress
New York Medical College Raymond DattwylerAntigen Capture Assays for Rapid Detection of Y. Pestis
New York University School of MedicineMartin BlaserDevelopment of furanones for treatment of anthrax
Northern California Institute of Research and Education Peter Eliash Risk Factors for Eczema Vaccinatum in Atopic Dermatitis
Northwestern University Lawrence Pinto Studies on Influenza B Virus BM2 Protein Ion Channel
Novobiotic Pharmaceuticals, LLCLosee LingNovel Antibiotics from Unculturable Actinomycetes
Ohio State University Woodbridge Foster Vector Survillance with Phytochemicals
Ohio State University Susheela Tridandapani SHIP-2 Influenza on Macrophage Fc Receptor Function
Oklahoma Medical Research FoundationShinichiro KurosawaPrimate Model and Pathogenesis of Anthrax Sepsis
Oncovir, Inc. Andres SalazarPoly-ICLC Prophylaxis Treatment of Ebola Virus Infection
Purdue University West Lafayette Suresh Mittal Adenoviral Vector-based Pandemic Influenza Vaccine
Rockefeller University Margaret Macdonald Studies on ZAP, a broad-spectrum alphavirus inhibitor
Rockefeller University Margaret Macdonald Host factors in the alphavirus replication complex
Rockefeller University Michael O'DonnellBiochemical Mechanism of Poxvirus Replication
Scripps Research Institute Michael Buchmeier Human T-cell Epitopes in SARS
Scripps Research Institute Kim Janda High-Throughput Identification of BoNT Inhibitors
Scripps Research Institute Stephen Mayfield Production of Antibodies in Algae for Biodefense
Southern Research Institute William ParkerPurine Analog Anti-Mycobacterial Drug Development
St Jude Children's Research HospitalJonathan McCullers Synergism Between Influenza Virus and Pneumococcus
Stanford University Julie TheriotActin Based Motility of a Bacterial Pathogen
State University New York Stony BrookJames Bliska Modulation of Host Signaling Functions by Yersinia Yops
Texas A&M University Health Science Center James Samuel Identification of T Cell Antigen For Q Fever Vaccination
Texas Agricultural Experiment Station Thomas Ficht Improved Brucella Vaccine Strains
Thomas Jefferson University Bernhard Dietzschold Generation of Novel Recombinant Rabies Virus Vaccines
Trudeau Institute, Inc.Troy Randall Generation of effective memory CD8 T cells to influenza
Tufts University Boston Abraham Sonenshein Clostridium difficile Toxin Gene Regulation
Tulane University of LouisianaTyler Curiel A Novel MAPK family in T. gondii
Umea University Anders Sjostedt Development of live Francisella tularensis vaccines
University of Alabama at Birmingham Wayne Brouillette New Influenza A Neuraminidase Inhibitors for Biodefense
University of California at DavisCharles Bevins Novel Defensins of Human Epithelia
University of California at DavisRenee Tsolis Characterization of the Brucella abortus virB Locus
University of California Los AngelesLinda BaumNipah Virus Pathobiology and Effects on Innate Immunity
University of California San DiegoSanjay Nigam SNPs in Handling of Smallpox Antivirals & Other Drugs
University of California San DiegoMaurizio Zanetti Genetically-Programmed APC Vaccines Against Viruses
University of California Santa BarbaraMichael MahanCross-Protective Vaccines vs. Emerging Infectious Agents
University of ChicagoPhilip Ashton-RickardtDevelopment and Persistence of Memory T Lymphocytes
University of ChicagoWei-Jen TangIntervention against anthrax edema factor (EF)
University of Ghent Walter FiersA Universal, M2-protein based influenza A Vaccine
University of Illinois at ChicagoLijun Rong Elucidatng the Entry Mechanism of Ebola Viruses
University of Illinois Urbana-Champaign David Kranz Receptor-Based Therapeutics for Enterotoxins
University of Illinois Urbana-Champaign Joanna Shisler Poxvirus regulation of NF-kB: Mechanisms for virulence
University of Illinois Urbana-Champaign James SlauchFunctional Analysis of Cu/Zn Superoxide Dismutase
University of Illinois Urbana-Champaign Richard Tapping Initiation of Toll-Like Receptor Signaling
University of Illinois Urbana-Champaign John Xu The Role of Host B Lymphocytes in Yersinia Pathogenesis
University of Iowa John HartyCTL Pathogenesis After Infection of Vaccinated Host
University of Maryland Baltimore Professional School Abdu Azad Generation of Genetically Attenuated Rickettsiae
University of Maryland Baltimore Professional School James Nataro Virulence in Enteroaggregative Escherichia coli
University of Maryland Baltimore Professional School Michael Donnenberg Molecular Basis of Localized Adherence in E. coli
University of Maryland Biotechnology Institute Osnat Herzberg Giardia drug targets: Structure, function and inhibitors
University of Massachusetts Medical School - Worcester John Leong Actin pedestal formation by EHEC O157:H7
University of Miami - Medical SchoolGeorge Munson Characterization of the ETEC Virulence Regulator Rns
University of Michigan at Ann ArborGrabiel NunezCryopyrin Signaling in Inflammation and Innate Immunity
University of Michigan at Ann ArborGrabiel NunezRole of Ipaf in Inflammation and Host Defense
University of Michigan at Ann ArborMary O'Riordan Use of host derived lipoate by Listeria monocytogenes
University of Minnesota - Twin CitiesYoji ShimizuPL 3-Kinase Gamma and T Cell-Mediated Antiviral Responses
University of North Carolina - Chapel Hill Jenny Ting M Tuberculosis and Host-Defense Mechanisms
University of North Carolina - Charlotte Kenneth PillerEfficacy of soybean-based vaccines using a model antigen
University of PennsylvaniaJohn MurrayHow do you build a parasite?
University of PennsylvaniaSteven ReinerControl of CD8+ Effector T Cell Differentiation
University of PittsburghBruce McClaneMechanisms of Action of C. perfringens Enterotoxin
University of Rochester Alice SijtsImmunogenicity of Listeria-derived antigens
University of South AlabamaHerbert Winkler Permeability of the Epidemic Typhus Rickettsia
University of Texas - San AntonioKarl Klose Sigma 54 and Vibrio cholerae Pathogenesis
University of Texas Health Center at TylerPeter Barnes Regulation of IFN-Gamma Production in Human Tuberculosis
University of Texas Medical Branch - Galveston Ashok Chopra Identification of New Antigens for a Plague Vaccine
University of Texas SW Medical Center - Dallas John FarrarType 1 Interferon-Regulated T Helper Development
University of Vermont & St. Agric CollegeGary Ward Functional Studies of Toxoplasma gondii AMA1 and AMA2
University of Washington Pamela FinkCharacterization of Recent Thymic Emigrants
University of Washington Pamela FinkImmunoregulation of Murine CD8+ T Cells
University of Washington Thomas HawnTLR5 and Pulmonary Innate Immunity
University of Washington Michael Katze Translational Control in Influenza Virus Infected Cells
University of Wisconsin - Madison Stacey Schultz-Cherry Lethality of H5N1 Influenza Virus is Linked to TGF-beta
University of Wisconsin - MadisonChristopher Olsen Host range restriction of human influenza viruses
University of Wisconsin - MadisonYoshihiro Kawaoka Influenza Virus Assembly
Vanderbilt University Neil Green High-throughput Drug Screen Against Botulinum Neurotoxin
Veritas, Inc. George OylerHigh Throughput Screens for Botulinum Toxin Therapeutics
Veterans Medical Research Foundation - San Diego Karl Hostetler Analogs of HPMPA for Treatment of Smallpox
Wadsworth Center Paul Masters Genetic Analysis of Coronavirus Assembly Interactions
Wake Forest University Health Sciences Elizabeth Hitbold Mechanisms of Listeria-Specific Immunity
Washington University Emil Unanue Immunity to Intracellular Pathogens
Washington UniversityVirginia Miller YsrRS regulon of Y. enterocolitica
Washington University David Sibley Protein secretion & intracellular survival by Toxoplasma
Weill Medical College of Cornell University Andrea Cerutti Regulation of Antibody Production by Innate Immune Cells
Weill Medical College of Cornell University Carl Nathan Targets in M. Tuberculosis:Stress Resistance & Repair
Wistar Institute Walter Gerhard RM2-Based Influenza Type A Virus Vaccine
Yale University Susan KaechRegulation of Memory CD8 T Cell Development
Yeshiva UniversityLouis Weiss Toxoplasma encephalitis in AIDS:Bradyzoite Regulations

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