Biodefense

Biodefense and Emerging Infectious Diseases Research Opportunities
Research Project Awards (R01/R56)

FY 2006

Institution	PI Name	Title
Australian National University	David Tscharke	CD8+ T cell specificity in mouse models of smallpox vaccination and challenge
Brigham and Women's Hospital	Geral Pier	Poly-N-acetyl glucosamine as a vaccine for bacterial pathogens
Burnham Institute for Medical Research	Maurizio Pellecchia	Potent and Safe Inhibitors of B. anthracis Lethal Factor
Case Western Reserve University	Clifford Harding	Class II MHC Transport and Function
CBR Institute for Biomedical Research	Michael Carroll	Regulation of immune response to influenza by innate immunity
Duke University	Meta Kuehn	Enterotoxin targeting and delivery mechanisms
Duke University	Herman Staats	Nasal Vaccines: Mode of Action, Composition & Delivery
East Carolina University	Roy Roop	Brucella Iron Metabolism in Host Macrophages
East Carolina University	Roy Roop	Brucella Stationary Phase Gene Expression and Virulence
Emory University	Richard Compans	Novel VLP vaccines for pandemic influenza virus
Emory University	Daniel Kalman	Inhibitors of Pox virus motility and release
Emory University	Tristram Parslow	Mechanisms of Genomic RNA Packaging in Influenza Virus
Georgetown University	Radhakrishnan Padmanabhan	Identification and Analysis of Flavivirus Protease and RNA Helicase Inhibitors
Georgia State University	Margo Brinton	Functional analysis of flavivirus genetic resistance.
Goteborg University	Jan Holmgren	Development of killed vaccine for Vibrio cholerae O139
Harvard University Medical School	Mercedes Becerra	Epidemiology of multidrug-resistant tuberculosis in Peru
Harvard University Medical School	James Chou	Structural basis for influenza amantadine-resistance
Henry M. Jackson Foundation for the Advancement of Military Medicine	Christopher Broder	Nipah Virus and Hendra Virus Entry and Virion Assembly
Institute for Cancer Research	Luis Sigal	Orthropoxvirus Pathogenesis and Vaccines
Johns Hopkins University	David Irani	Protection of Mice From Lethal Alphavirus Encephalitis
Johns Hopkins University	Raphael Viscidi	Virus-Like Particle Vaccine for SARS-CoV
LA Biomedical Research Institute, Harbor UCLA Medical Center	Michael Yeaman	Microbicidal Proteins from Platelets
La Jolla Institute for Molecular Medicine	Chun-Ming Huang	Immunological Secretomes of the Early Anthrax Infection
La Jolla Institute for Allergy and Immunology	Michael Croft	TNFR Members in T Cell Immunity to Vaccinia
La Jolla Institute for Allergy and Immunology	Mitchell Kronenberg	Recognition of bacterial antigens by NKT cells
Massachusetts General Hospital	Ramnik Xavier	Genomic Approaches to Host-Pathogen Interactions
Massachusetts Institute of Technology	Jianzhu Chen	Development and Maintenance of Memory CD8 T Cells
Medical College of Wisconsin	Dara Frank	Regulation of Gene Expression in Francisella
Mount Sinai School of Medicine of NYU	Adolfo Garcia-Sastre	Virulence factors of influenza virus: The NS1 protein
Nastech Pharmaceutical Company, Inc.	Qing Ge	Development of siRNAs to Prevent and Treat Influenza Infection
National Jewish Medical & Research Center	Laurel Lenz	Immune Modulation by Bacterial Autolysins
New York Medical COllege	Yuk-Ching Tse-Dinh	Bacterial cell killing topoisomerase I--DNA lesion
New York University School of Medicine	Franco Celada	To model crossreacting T-memory of virus-infected mice
Pennsylvania State University Hershey Medical Center	Chris Norbury	Leukotrienes in Innate and Adaptive Antiviral Immunity
Rockefeller University	F. Nina Papavasilious	The role of AID protein in the host response to viral infection
Scripps Research Institute	Michael Mcheyzer-Williams	Innate Regulation of Adaptive Immunity
Scripps Research Institute	Michael Mcheyzer-Williams	Development of Antigen-Specific B Cell Memory
Scripps Research Institute	Michael Oldstone	Arenavirus Receptor-Structure/Function Studies
Scripps Research Institute	Erica Ollmann Saphire	Ebola Viral Glycoproteins: Structural Analysis
Seattle Biomedical Research Institute	Nancy Freitag	Listeria Virulence Gene Expression Within Host Cells
Sloan-Kettering Institute for Cancer Research	Derek Tan	Siderophore Biosynthesis Inhibitors as New Antibiotics for Biodefense
Southwest Foundation for Biomedical Research	Rebecca Rico-Hesse	Dengue Virus Determinants of Virulence and Transmission
St. Jude Children's Research Hospital	Peter Doherty	Protective Cell-Mediated Immunity Against Lethal H5N1 Influenza A Viruses
St. Jude Children's Research Hospital	Tina Izard	Pathogen-host Interactions that Remodel the Cytoskeleton
St. Jude Children's Research Hospital	Stephen White	Novel Inhibitors to DHPS to Probe Catalytic Mechanism & Therapeutic Potential
Stanford University	Eugene Butcher	Intestinal Lymphocyte Trafficking
Stanford University	Julie Theriot	Surface protein dynamics in live bacterial pathogens
Texas A&M University Health Science Center	Vernon Tesh	Pathogenic Mechanisms of Shiga Toxins
Texas Agricultural Experiment Station	Guan Zhu	Fatty Acid Biosynthesis in Cryptosporidium parvum
Thomas Jefferson University	Kishore Alugpalli	B1B lymphocytes generate T cell-independent memory
Thomas Jefferson University	Scott Dessain	Human Monoclonal Antibodies that Bind Botulinum Toxins
Trudeau Institute, Inc.	Frances Lund	Generation and maintenance of influenza-specific plasma and memory B cells
Trudeau Institute, Inc.	David Woodland	Memory T cell subsets and pulmonary immunity
Tufts University, Boston	Andrew Camilli	Role of c-diGMP signaling in Vibrio cholerae virulence
Tufts University, Boston	Sam Telford	Perpetuation of Francisella tularensis
Tufts University, Medford	David Kaplan	Bioemulsifying Vaccine Delivery System for Immunomodulation
Tulane University of Louisiana	Robert Garry	Peptide inhibitors of dengue virus infectivity
University of Maryland Baltimore Professional School	Abdu Azad	Rickettsia felis and other emerging rickettsial pathogens
University of Massachusetts Medical School, Worcester	Victor Boyartchuk	Genetic control of immune response to Listeria infection
University of Massachusetts Medical School, Worcester	Katherine Fitzgerald	Regulation of Type I Interferon Gene Expression in the Innate Immune Response
University of Medicine and Dentistry of New Jersey - R. W. Johnson Medical School	Victor Stollar	Regulation of Sindbis Virus Subgenomic RNA Synthesis
University of Alabama at Birmingham	Casey Weaver	Post-Thymic T-Cell Functional Heterogeneity
University of Alabama at Birmingham	Allan Zajac	Helper-Dependent CD8 T Cell Memory
University of Arizona	Jorge Giron	YagZ Pilus Adhesin of Attaching and Effacing E. coli
University of California, Berkeley	Carolyn Bertozzi	Mycobacterial Sulfation Pathways
University of California, Davis	Thomas Scott	Measuring Entomological Risk for Dengue
University of California, Irvine	Naomi Morrissette	Mechanisms of Dinitroaniline Action, Selectivity and Resistance
University of California, Irvine	Andre Ouellette	Studies of Alpha-Defensins in Primate Innate Immunity
University of California, Los Angeles	Peter Bradley	The Role of Toxoplasma Rhoptries in Host Cell Infection
University of California, Los Angeles	Genhong Cheng	Viral Mediated Type I Interferon Induction
University of California, Los Angeles	Marcus Horwitz	A TB Vaccine for AIDS Patients
University of California, Los Angeles	Marcus Horwitz	Development and Testing of New Tuberculosis Vaccines
University of California, San Diego	Partho Ghosh	Protein Translocation by the Type III Secretion System
University of California, San Diego	Partho Ghosh	Mechanism of Host Cell Invasion by Microbial Pathogens
University of California, San Francisco	Averil Ma	Interleukin 15 Receptor and Lymphoid Homeostasis
University of Florida	Frederick Southwick	Anthrax Toxins Impair Phagocyte Actin-based Motility
University of Georgia	Boris Striepen	Biology of the Apicomplexan Plastid
University of Iowa	Robert Ashman	Mechanism of Action of Inhibitory CpG Oligonucleotides
University of Iowa	Gregory Gray	Prospective Studies of Avian Influenza Transmission in Asia
University of Iowa	John Harty	Accelerated CD8 T cell memory after DC vaccination
University of Kentucky	Anthony Sinai	Blockade of host apoptosis by Toxoplasma gondii
University of Kentucky	Susan Straley	YopM and protective innate defenses against plague
University of Louisville	Yousef Abu Kwaik	Molecular pathogenesis of Francisella tularensis
University of Maryland Baltimore Professional School	Eileen Barry	Shigella dysenteriae vaccine construction
University of Maryland Baltimore Professional School	James Kaper	Development of a Live Oral Cholera Vaccine
University of Maryland Baltimore Professional School	Marcela Pasetti	Immune Responses to Biodefense Vaccines Early in Life
University of Maryland, College Park Campus	Jonathan Dinman	Characterization of the SARS-CoV frameshift signal
University of Massachusetts Medical School, Worcester	Shan Lu	Development of multi-antigen subunit SARS vaccines
University of Michigan at Ann Arbor	Ronald Larson	A Microfabrication Device for Rapid, Portable, Viral Genome Analysis
University of Minnesota, Twin Cities	Courtney Aldrich	Design of antituberculosis agents that target siderophore biosynthesis
University of Minnesota, Twin Cities	Marc Jenkins	Modular Subunit Vaccine for Salmonella
University of Minnesota, Twin Cities	Marc Jenkins	Tracking CD4+ Memory T Cells in Vivo
University of Pennsylvania	Laurence Turka	Expression and function of the TLRs on T cells
University of Pittsburgh at Pittsburgh	Andrea Gambotto	A Preventative Adenoviral-Based H5N1 Influenza Vaccine
University of Rochester	Sanjeev Sahni	Regulatory Oxygenases in Vasculopathic Rickettsioses
University of Texas Health Sciences Center, Houston	Rick Wetsel	Complement Anaphylatoxin Receptors in Inflammation
University of Texas M.D. Anderson Cancer Center	Kimberly Schluns	Regulation of memory CD8 T Cell homeostasis by IL-15Ra+
University of Texas Medical Branch, Galveston	Alan Barrett	West Nile Virus: Epidemiology and Mosquito Competence
University of Texas Medical Branch, Galveston	Charles Fulhorst	Viral determinants of hantavirus pulmonary disease in the hamster
University of Texas SW Medical Center, Dallas	James Forman	Immune Potential of Animal Lacking Class IA Molecules
University of Texas SW Medical Center, Dallas	David Hendrickson	Campylobacter jejuni flagellar regulation and synthesis
University of Toronto	Jeremy Mogridge	Characterization of Anthrax Lethal Toxin
University of Washington	Ferric Fang	The Salmonella Typhirium Sigmae Regulon
University of Washington	David Koelle	Vaccinia: T-cell immunity and homing to skin
University of Washington	Samuel Miller	Salmonella pathogenicity island 2 effector proteins
University of Washington	Kelly Smith	Mucosal Innate Immunity to Salmonella Infection
University of Wisconsin, Madison	Christopher Coe	Maternal flu infection and brain development in primates
University of Wisconsin, Madison	Yoshihiro Kawaoka	Pandemic Potential of H5N1 Influenza Viruses
University of Wisconsin, Madison	Que Lan	Intracellular transfer of cholesterol in mosquitoes
Vanderbilt University	Timothy Sterling	Fluoroquinolone Resistance in M. Tuberculosis
Washington University	Phillip Tarr	Nucleotide Polymorphisms in Enteric Pathogens
Washington University	Samuel Stanley	Molecular Dissection of E. Histolytica Pathogenesis
Wistar Institute	Edward John Wherry	Regulation of exhaustion and altered CD8 T cell memory during chronic Infection
Yale University	Akiko Iwasaki	Viral recognition by plasmacytoid dendritic cell
Yale University	Craig Roy	Modulation of Host Cell Functions by Coxiella burnetii
Yeshiva University	David Fidock	Role of pfcrt in chloroquine resistance in P. falciparum

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