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Biodefense

NIAID Small Business Biodefense Program

FY 2006 Awards

InstitutionPI NameTitle
Adenosine Therapeutics, LLCShannon WilliamsSafety of A2A Adenosine Agonist for Treatment of Sepsis
AFG Biosolutions, Inc.Kenneth AlibekNisin as a decontaminant for B. anthracis spores on human skin
Akonni Biosystems, Inc.Charles DaitchMicrofluidic Controlled Gel-Drop Microarrays for Biothreat Diagnostic Devices
Alnylam PharmaceuticalsAntonin DefougerollessiRNA Intervention Strategies for Influenza Infection
Alpha Universe, LLCAlexey ZdanovskyDevelopment of novel proteins as a defence against potential biothreat agents
Atom Sciences, Inc.Richard HurtBioagent Characterization by Iterative Extension
Autoimmune Technologies, LLCRobert GarryPeptide drugs against influenza virus
Avant Immunotherapeutics, Inc.Sims KochiDevelopment and cGMP Manufacture of a Vitrified Typhoid Vaccine
Avidbiotics CorporationDavid William MartinHost Range Diversity of Bacteriophage for Y. pestis
BiotheraMyra PatchenOral beta-glucan treats hematopoietic injury resulting from acute radiation expos
Cellerant Therapeutics, Inc.Ramkumar MandalamApplication of Expanded Myeloid Progenitors for Infection (Phase II)
Cyto Pulse Sciences, Inc.Alan KingDNA Vaccine Delivery System for Biodefense with dengue
DMX, Inc.Hao ShenNew attenuated anthrax vaccine
Dor Biopharma, Inc.Robert Newton BreyDevelopment of a mucosally administered trivalent serotype A,B, E botulinum vaccine
EIC Laboratories, Inc.R. David RauhReagentless Immunosensors Based on Biofunctionalized Nanotubes
Endacea, Inc.Constance VanceA Novel Treatment in a Bioterrorism Model of Pneumonic Plague Targets A1 ARs
Functional Genetics, Inc.Roxanne DuanDevelopment of Therapeutic Agents Against Influenza by Targeting Host Factors
Gene Therapy Systems, Inc.Alan GreenerScreening Complete TB Proteome for Protective Antigens
Genomics USA, Inc.Krishna JayaramanPopulation Scale HLA Typing for Homeland Defense
Genvec, Inc.C. Richter KingNovel Adenovirus Vectors for Biodefense Vaccines
Hawaii Biotech, Inc.Sherri MillisStructure Based Design of Dengue Virus Fusion Inhibitors
Hawaii Biotech, Inc.Sherri MillisDiscovery of West Nile Virus Protease Inhibitors
Hawaii Biotech, Inc.Sean O'MalleyOptimization of Small Molecule Botulinum Neurotoxin Inhibitors
IDX Labs, Inc.Eric HouptReal-time PCR diagnostic kit for Giardia and Cryptosporidium
Inbios International, Inc.Antonio Campos-NetoAntigen Detection Assay for Tuberculosis
Inbios International, Inc.William John MorrowDevelopment of rapid detection tests for Brucella species
Indevr, LLCMatthew FerrisMonitoring System For Vector-Based Influenza Vaccine
Innovative Surface Technologies, LLCKristin TatonMultianalyte Nanomagnetic Biosensor Array for Pathogen Detection
Integral MolecularTiffani GreeneSMART Arrays for Pathogen Detection
Intrinsic Bioprobes, Inc.Eric NiederkoflerMass Spectrometry Assays for Biodefense
Investigen, Inc.Peter DaileyEasy, fast, point of care nucleic acid based detection of pulmonary tuberculosis
Inviragen, LLCDan StinchcombMucosal modified vaccinia Ankara-based plaque vaccines
Juvaris Biotherapeutics, Inc.Jeff FairmanLipid/DNA/Antigen Complexes for Influenza A Viral Vaccination
Juvaris Biotherapeutics, Inc.Jeff FairmanInnate Immune Stimulation as a Pathogen Countermeasure
L2 Diagnostics, LLCKaren AnthonySmall Molecule Alanine Racemase Inhibitors as Novel Therapeutics for Tuberculosis
L2 Diagnostics, LLCMichel LedizetAntivirals Targeting Flavivirus Envelope Proteins
L2 Diagnostics, LLCYorgo ModisBroad-Spectrum Therapeutic Human Antibodies for Dengue Virus Infections
Lynntech, Inc.Adrian DenvirElectrochemical Method for Viable Pathogen Detection
Lynntech, Inc.J. Tim WhartonAn Integrated Optical DNA Detector for Portable PCR
Lynntech, Inc.Season WongA Nanocrystal-Based Device for Point-of-Care Molecular Differential Diagnostics
Maxthera, Inc.Ania KnapNew Broad-Acting Cell Wall Antibiotics for Biodefense
Maxygen, Inc.Robert Gerald WhalenVaccines for Eastern and Western Equine Encephalitis Viruses
Microbiotix, Inc.Arnab BasuIdentification of Ebola Virus Entry Inhibitors
Microbiotix, Inc.Michelle ButlerDevelopment of Inhibitors of Mycobacterium Tuberculosis DNA Replication
Microbiotix, Inc.Donald MoirDiscovery of B. pseudomallei therapeutics for Biodefense
Midi, Inc.Myron SasserRapid Susceptibility Testing of MDR M. tuberculosis- Phase II
Molecular Targeting Technology, Inc.Matthias Johannes SchnellA novel rhabdovirus-based anthrax vaccine
Novobiotic Pharmaceuticals, LLCLosee Lucy LingDeveloping Novel Antibiotics Against Yersinia pestis
Physical Optics CorporationGregory ZeltserMicrofluidic Refractometric Biosensor
Pinnacle PharmaceuticalsLarisa DedkovaAnti-infection Agents that Target Protein Synthesis
Planet Biotechnology, Inc.Keith WycoffBotulinum Toxin Plantibodies
Planet Biotechnology, Inc.Keith WycoffNovel Therapy for Pulmonary Anthrax
Platypus Technologies, LLCBarbara IsraelBiophotonic detection of WNV Abs from Multiple Species
Polymedix, Inc.Richard ScottTherapeutic Development of Antimicrobial Biomimetics
Promiliad Biopharma, Inc.Dennis WrightPotent and selective DHFR inhibitors for treating Cryptosporidiosis
Prothera Biologics, LLCSteven OpalRole of Inter-alpha Inhibitors in Anthrax Intoxication
RX3 Pharmaceuticals, Inc.John FinnNovel Antibacterial Designed Multiple-Target Ligands
RX3 Pharmaceuticals, Inc.Mark Alan StidhamNovel Bacterial Cell Wall Biosynthesis Inhibitors for Biodefense Therapeutics
Scarab Genomics, LLCFrederick BlattnerClean-Genome vaccines against biodefense agents
Sequella, Inc.Venkata ReddyNovel mycobacterial translocase I inhibitors--a new class of anti-TB drugs
Siga Technologies, Inc.Sean AmbergAntiviral Drugs for Lassa Fever Virus
Siga Technologies, Inc.Dennis HrubyBacterial Commensal Vector Delivery/Smallpox Vaccine
Siga Technologies, Inc.Robert JordanSmall Molecule Inhibitors of Smallpox Virus Replication
Syntiron, LLCLaura WonderlingSalmonella vaccination with iron-regulated membrane proteins
Techlab, Inc.Joel HerbeinNew Rapid Diagnostic Tests for Amebiasis
Tengen Biomedical Co.Xiaowu PangDevelopment of Pseudoinfectious VLP as Novel JEV Vaccine
TSRL, Inc.Phillip KishBile acid conjugates to improve the oral bioavailability of anti-influenza drugs
Vaxin, Inc.De-Chu Christopher TangIn-ovo vaccination/avian influenza/bird/human
Zuchem, Inc.David DoddsSynthesis and Testing of Neoglycoside Glycopeptide Prototypes

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