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Biodefense

Biodefense and Emerging Infectious Diseases Research Opportunities
Research Project Awards (R01/R56)—FY2007 Awards

Institution
PI Name
Title
Albany Medical College of Union Univ. Metzger, Dennis W. Regulation of B Cell Function by Interleukin 12
Benaroya Research Inst. at Virginia Mason Hamerman, Jessica A. Regulation of Inflammatory Signaling during the Innate Immune Response
Brigham and Women's Hospital Wang, Julia Y. Designing Potent Anthrax Vaccine with Engineered Protective Antigen
Brookhaven Science Assoc-Brookhaven Lab Li, Huilin Structural Studies of the M. Tuberculosis Proteasome and Proteasomal ATPase
Brown University Brossay, Laurent NK T Cell Interactions with NK Cells during Viral Infection
Burnham Institute for Medical Research Osterman, Andrei L. Genomics of Coenzyme Metabolism in Bacterial Pathogens
Case Western Reserve University Van Den Akker, Focco Mechanistic Studies and Inhibition Strategies for Antibiotic Resistance
Case Western Reserve University Bonomo, Robert A. Multi-Drug-Resistant Acinetobacter Baumannii
Case Western Reserve University Mandalakas, Anna M. The Utility of Interferon-Gamma Release Assays in TB-HIV Co-infected Children
Children's Hospital Boston Watnick, Paula I. Drosophila Melanogaster as a Model Host for Vibrio Cholerae
Children's Hospital Boston Choe, Hyeryun A Cellular Receptor for New World Arenaviruses
Children's Hospital Boston Watnick, Paula I. Vibrio Cholerae Biofilm Development
Clemson University Temesvari, Lesly A. Role of Lipid Rafts and Phosphoinositides in E. Histolytica Virulence
Colorado State University-Fort Collins Franz, Alexander William Eduard RNAi as a Modulator of Arbovirus Vector Competence in Transgenic Aedes Aegypti
Colorado State University-Fort Collins Crick, Dean C. Menaquinone Biosynthesis: A Drug Target in Gram-Positive Bacteria
Cornell University Ithaca Whittaker, Gary R. Endocytosis of Influenza Viruses
Dartmouth College Enelow, Richard I. TNF Processing in Pulmonary Immunopathology
Dartmouth College Kull, F. Jon Structural Analysis of Vibrio Cholerae Virulence Gene Regulatory Proteins
Dartmouth College Taylor, Ronald K. Hierarchy within Environmental Regulons
Dartmouth College Skorupski, Karen A. New Mechanisms for Regulating Virulence Gene Expression
Emory University Stephens, David S. Molecular Basis of Mef-Mediated Antibiotic Resistance in Streptococcus Pneumoniae
Fudan University Xu, Biao Social and Biomedical Risk Factors for Multi-Drug-Resistant TB in Rural China
Harvard University (Medical School) Mekalanos, John J. Genetic and Ecological Factors in Transmissibility and Epidemic Cycle of Cholera
Institute for Cancer Research Seeger, Christoph Inhibition of the Interferon Response by West Nile Virus
Institute for Cancer Research Sigal, Luis J. MHC Class I Antigen Presentation in Viral Infections
Institute for Systems Biology Aderem, Alan A. Recognition of Bacterial Flagellin by Macrophages
Iowa State University Kohut, Marian L. Exercise-Induced Immunomodulation in the Aged: Mechanisms
Johns Hopkins University Rasgon, Jason L. Genetic Basis of WNV Vector Competence in Culex Tarsalis
Johns Hopkins University Chen, Lieping Memory T Lymphocyte-Mediated Innate Immunity
La Jolla Inst. for Allergy & Immunolgy Von Herrath, Matthias G. How IL-10R Blockade Can Resolve Persistent Viral Infections
La Jolla Inst. for Allergy & Immunolgy Kronenberg, Mitchell Indirect Recognition of Microbes by NKT Cells
La Jolla Inst. For Allergy & Immunolgy Sette, Alessandro D. Immunogenetics of Chinese-Origin Rhesus Macaques Used in Biodefense Research
Los Alamos Nat. Secty-Los Alamos Nat. Lab Cai, Hong Nucleic Acid Dipstick for Rapid Avian Flu Detection at Point-of-Care
Loyola University Chicago Knight, Katherine L Somatic Diversification of Immunoglobulin Genes in Galt
Massachusetts General Hospital Ausubel, Frederick M. Novel Whole-Animal Screens for Antimicrobials
Mayo Clinic Coll. of Medicine, Rochester David, Chella S. HLA Class II Transgenic Mice as Models for Bacterial Superantigen Induced Disease
Mayo Clinic Coll. of Medicine, Rochester David, Chella S. A Humanized Transgenic Mouse Model for Studying Staphylococcal Enterotoxin B
Michigan State University Walker, Edward D. Larval Mosquito Feeding and Microbial Interactions
Microbial Novoteqs, Inc. Fang, Hong Yeast-Based High-Throughput Assays for Proteases of Category A, B, & C Viruses
New York Blood Center Jiang, Shibo SARS-CoV S Protein Receptor-Binding Domain-Based Vaccines
New York Medical College Mordue, Dana G. Toxoplasma Gondii Evasion of Immune Effecter Mechanisms
Northeastern University Lewis, Kim Screen Development for Antimicrobial Prodrugs
Northwestern University Barron, Annelise Emily Ampetoids as Biostable Functional Mimics of Antimicrobial Peptides
Northwestern University Lamb, Robert A. Structure and Function of the Influenza Virus Genome
Ohio State University Gunn, John S. Bile, Biofilms, and Salmonella Gallbladder Carriage
Oregon Health & Science University Crosa, Jorge H. Iron and Pathogenesis in Infections by Vibrio Vulnificus
Oregon Health & Science University Crosa, Jorge H. Iron Uptake as a Virulence Factor in Pathogenic Vibrios
Oregon State University Yin, Xihou Genetic and Chemical Approaches to Novel Lipid II Binding Peptide Antibiotics
Rensselaer Polytechnic Institute Linhardt, Robert J. Stable Carbohydrate Libraries in Infectious Disease
Rutgers, The St. Univ. of NJ, New Brunswick Tumer, Nilgun E. Mechanism of Cytotoxicity of Ricin
Rutgers, The St. Univ. of NJ, New Brunswick Ebright, Richard H. Inhibitors of Bacterial RNA Polymerase: "Switch Region"
Saint Louis University Hoft, Daniel F. Role of Gamma/Delta T Cells in Vaccine Induced Immunity
Scripps Research Institute Wong, Chi-Huey Carbohydrate-Based Antiinfective Agents
Scripps Research Institute Mcheyzer-Williams, Michael G. Development of Antigen-Specific T Cell Memory
Scripps Research Institute Hoch, James A. Signal Transduction Networks in Bacillus Anthracis
Scripps Research Institute De La Torre, Juan C. Reverse Genetics of Arenaviruses
Sloan-Kettering Institute for Cancer Res. Tan, Derek S. Siderophore Biosynthesis Inhibitors as New Antibiotics for Biodefense
Southern Research Institute Li, Rongbao Structure of M. Tuberculosis Adenosine Kinase and Design of Antimicrobial Nucle
Stanford University Schneider, David S. Adaptation in the Drosophila Innate Immune Response
Stanford University Boothroyd, John C. Strain-Specific Host-Pathogen Interactions in Toxoplasmosis
Stanford University Boothroyd, John C. Developmental Biology of Toxoplasma
Suny Downstate Medical Center Quale, John M. Study of Mechanisms Leading to Multidrug-Resistant K. Pneumoniae and A. Baumannii
Thomas Jefferson University Hooper, Douglas Craig Passive Immunization for Neurotropic Virus Infection
Thomas Jefferson University Eisenlohr, Laurence Crane The Basis for MHC Class II-Restricted Proteasome-Dependent Epitopes
Trudeau Institute, Inc. Lund, Frances E. NAD and CD38: Modulators of Inflammation and Immunity
Trudeau Institute, Inc. Randall, Troy D. Function of NALT in Nasal Immunization to Heterotypic Strains of Influenza
Trudeau Institute, Inc. Swain, Susan L. CD4 T Cell Protection in the Lung
Univ. of Massachusetts Med. Sch. Worcester Sassetti, Christopher M. Mce Transport Systems of Mycobacterium Tuberculosis
Univ. of Massachusetts Med. Sch. Worcester Marshall, William Mechanisms of Vaccinia Virus Innate Immune Inhibition
Univ. of Massachusetts Med. Sch. Worcester Welsh, Raymond M. B Cell Activation during Viral Infection
Univ. of Massachusetts Med. Sch. Worcester Kelliher, Michelle A. Rip Proteins in Innate Immune Signaling
Univ. of Med./Dent. of NJ-NJ Medical School Perlin, David S. Mechanism of Clinical Resistance to Echinocandin Antifungal Drugs
Univ. of Med./Dent. of NJ-NJ Medical School Drlica, Karl A. Lethal Action of Fluoroquinolones with Non-growing Mycobacterium Tuberculosis
University of Adelaide Paton, Adrienne W. Characterization of a Novel AB5 Cytotoxin
University of Alabama at Birmingham Cooper, Max D. Characterization of the Lamprey Adaptive Immune System
University of Alabama at Birmingham Zajac, Allan J. Regulation of T Cell Activity during Chronic Infections
University of California Berkeley Welch, Matthew D. Manipulation of the Actin Cytoskeleton by Spotted Fever Group Rickettsia
University of California Davis Baumler, Andreas J. Analysis of Salmonella Typhimurium Adhesins
University of California Los Angeles Lee, Benhur Envelope-Receptor Interactions in Nipah and Hendra Virus Pathobiology
University of California San Diego Raz, Eyal The Diverse Contribution of TLR Pathways to Intestinal Homeostasis
University of California San Diego Fahey, Robert C. Whole Cell and Essential Enzyme Screening Assays for Mycothiol Biosynthesis
University of California San Diego Gillin, Frances D. Centrosomal Proteins in Giardia Differentiation
University of California San Diego Moore, Bradley S. Biosynthesis of the Antibiotic Polyketide Enterocin
University of California San Diego Gallo, Richard L. Cathelicidins in Skin Immunity
University of California San Francisco Voigt, Christopher A. System Dynamics of the Salmonella Virulence Regulatory Network
University of California San Francisco Ortiz De Montellano, Paul R. Oxygen Sensors and P450 Monooxygenases in Mycobacertium Tuberculosis
University of California San Francisco Hopewell, Philip C. Population-Based Molecular Epidemiology of Tuberculosis
University of Cape Town Hatherill, Mark Diagnostic Yield of Induced Sputum for Rapid Diagnosis of Pulmonary Tuberculosis
University of Central Florida Teter, Kenneth R. Toxin Thermal Instability and Its Role in Host-Toxin Interactions
University of Chicago Daum, Robert S. Spread of Community-Acquired MRSA among Household Contacts
University of Chicago Schneewind, Olaf Surface Proteins and Sortases of Bacillus Anthracis
University of Chicago Chong, Anita S. Mechanistic Studies on Listeria Infection and Inhibition of Allograft Tolerance
University of Chicago Mcleod, Rima L. Treatment of Congenital Toxoplasmosis
University of Chicago Wang, Chyung-Ru The Role of MHC Class Lb in T Cell Development and Infectious Disease
University of Cincinnati Weiss, Alison A. Shiga Toxin Production and Role in Pathogenesis
University of Colorado at Boulder Detweiler, Corrella Persistent Systemic Infection of Mice by Salmonella Enterica
University of Colorado Denver/Hsc Aurora Kedl, Ross M. IFNalphaBeta-Dependent and -Independent TLR/CD40 Synergy
University of Colorado Denver/Hsc Aurora Holmes, Randall K. Genetic Analysis of Cholera Toxin Structure and Function
University of Connecticut Sch. of Med./Dnt. Cauley, Linda S. Antigen Presentation after Influenza Virus Infection
University of Florida Moyer, Richard W. Poxvirus Proteins Involved in Virion Binding, Membrane Fusion, & Entry into Cells
University of Florida Johnson, Howard M. Study of Gamma Interferon Agonists/Mimetics
University of Georgia (Uga) Kissinger, Jessica C. Genome Evolution, Innovation, and Adaptation in the Apicomplexa
University of Georgia (Uga) Fu, Zhen F. Developing Avirulent Rabies Virus Vaccines
University of Illinois at Chicago Mankin, Alexander S. New Mechanism of Resistance to Oxazolidinone Antibiotics in Staphylococcus Aureus
University of Iowa Legge, Kevin L. Role of Dendritic Cells in Immunity to Pulmonary Influenza Virus Infections
University of Iowa Harty, John T. Regulation of T Cell Homeostasis by IFN-Gamma
University of Kansas Lawrence Picking, Wendy L. Control of Type III Secretion in Shigella by lpaD
University of Kentucky Straley, Susan C. YopM and Protective Innate Defenses against Plague
University of Maryland Baltimore Lukashevich, Igor S. Recombinant Yellow Fever 17D-Lassa Vaccine
University of Maryland Baltimore Sztein, Marcelo B. Immune Mechanisms of Protection in S Typhi Vaccines
University of Maryland Baltimore Donnenberg, Michael S. The eae Gene Cluster of Enteropathogenic E. coli
University of MD Biotechnology Institute Lu, Wuyuan Inhibition of Anthrax Lethal Factor by Alpha-Defensins
University of Miami-Medical School Plano, Gregory V. Control of Virulence Protein Export in Yersinia Pestis
University of Michigan at Ann Arbor Chapman, Matthew R. Assembly of Curli Fibers by Escherichia coli
University of Michigan at Ann Arbor Krukonis, Eric S. Regulation of Vibrio Cholerae Virulence by ToxR and TcpP
University of Minnesota Twin Cities Jameson, Stephen C. Homeostatic Proliferation and Memory CD8 T Cells
University of Nebraska Lincoln Bilder, Christopher R. Disease Detection and Prevalence Estimation through Informative Group Testing
University of New Mexico Albuquerque Ebel, Gregory David Quasispecies Dynamics in Arborvirus Persistence, Emergence, and Fitness
University of Pennsylvania Rubin, Harvey Characterization of NADH Type II Oxidoreductase from Mycobacterium Tuberculosis
University of Pennsylvania Zhu, Jun Analysis of Gene Regulation of Vibrio Cholerae Infection
University of Pennsylvania Hunter, Christopher A. Immunopathogenesis of Toxoplasmic Encephalitis
University of Pittsburgh at Pittsburgh Salter, Russell D. Interaction of Microvesicles and Bacterial Toxins with Immune Cells
University of Rochester Ward, Brian M. Protein Interactions Involved in Orthopoxvirus Envelopment
University of Rochester Crispe, Ian Nicholas TLR-4 in Liver Immunoregulation
University of Texas Hlth. Sci. Ctr. San Antonio Dube, Peter H. Role of IL-6 in the Pathogenesis of Y. Enterocolitica Infection
University of Texas M.D. Anderson Cancer Ctr. Cao, Wei Receptors of Plasmacytoid Dendritic Cells and Their Ligands
University of Texas Medical Br. Galveston Makino, Shinji Analysis of SARS Coronavirus-Host Cell Interactions
University of Virginia Charlottesville Ramakrishnan, Girija Iron Uptake Mechanisms of Francisella Tularensis
University of Virginia Charlottesville Petri, William A. Structure and Function of E. Histolytica Adherence Lectin
University of Washington Ramakrishnan, Lalita Host Responses to Mycobacterium Infection in Zebrafish
University of Wisconsin Madison Kwon, Glen S. Artificial Polymeric Lipoproteins as Drug Carriers
University of Wisconsin Madison Thorson, Jon Scott In Vitro Glycorandomization of Natural Products
Vanderbilt University Van Kaer, Luc Mechanisms and Consequences of iNKT Cell Anergy
Vanderbilt University Forster, Anthony C. Directed Evolution of Inhibitors of Anthrax Toxin
Washington University Sibley, L. David Targeting the Actin Cytoskeleton in Parasites
Washington University Diamond, Michael S. Antibody-Based Protection against Dengue Virus
Washington University Hultgren, Scott J. Structure of Proteins Involved in Bacterial Pathogenesis
Washington University Clifton, Sandra W. Comparative Genomics in the Enterobateriaceae
Weill Medical College of Cornell Univ. Worgall, Stefan Immunity Induced by Modified Adenovirus Fiber
Yale University Agaisse, Herve F. JAK/STAT Signaling in Drosophila Acute Phase Response
Yale University Galvani, Alison P. Optional Influenza Vaccine and Population Adherence
Yale University Agaisse, Herve F. High-Throughput Assays for Imaging Human Intracellular Pathogen Infections
Yeshiva University Weiss, Louis M. New Opportunistic Infections in AIDS Microsporidiosis

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