Medical Countermeasures Against Chemical Threats

Respiratory Tract

Short-Term Goals

• Identify and validate appropriate in vitro systems and animal models for preclinical testing of drugs to treat chemically induced injury to the upper and lower respiratory tract
• Identify products approved by the FDA for other indications that have potential for the treatment and/or prevention of chemically induced pulmonary edema
• Conduct appropriate studies to document the safety and efficacy of commonly used anti-inflammatory drugs following acute exposure to chemicals such as chlorine and phosgene
• Assess the effectiveness of current medical interventions for lung injury as they apply to the treatment of chemically induced pulmonary edema
• Develop collaborations among academia, government, nonprofit organizations, clinical research networks, and research centers that are specifically focused on chemical agents that induce pulmonary edema
• Develop a database and registry of individuals exposed to high quantities of toxic chemicals to the respiratory tract

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