National Institute of Allergy and Infectious Diseases



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HIV/AIDS

Topical Microbicides

Goals

The main goal of the NIAID HIV Topical Microbicide Reseach Program is to support research that leads to identification and development of safe, effective, and acceptable topical microbicides. NIAID’s topical microbicide research is outlined in the NIAID Topical Microbicide Strategic Plan (PDF), and includes basic research through preclinical development and clinical trials. More specifically, NIAID’s microbicide research objectives aim to support

Fundamental research to delineate the early steps in HIV infection and transmission at mucosal surfaces in cervicovaginal and rectal tissues
Discovery and development of safe and effective formulations and delivery methods
Development and utilization of suitable animal models for safety and efficacy testing
Research into the acceptance and use of microbicides by conducting prevention and behavioral studies
Exploratory Phase I clinical trials to assess the relevance of and validate new approaches for determining the safety and efficacy of candidate microbicides
Iterative preclinical to clinical translational research to evaluate and optimize topical microbicide formulations and strategies
Clinical trials to determine safety, efficacy/effectiveness, and acceptability of candidate topical microbicides