Simian Vaccine Evaluation Units (SVEU) Abstracts
Advanced BioScience Laboratories
Kensington, MD
Dr. Phillip Markham
HIV vaccine studies conducted by this contract involve:
- Evaluation of the breadth of immune responses generated by consensus CON-S envelope vaccines compared to single clade B envelope vaccines.
- Evaluation of Alphavirus virus-like replicon particle (VRP)/HIV vaccines.
- Evaluation of immunogenicity of measles virus vector/HIV vaccines; immunogenicity and efficacy of measles virus vector/SIV vaccines.
- Assessment of immunogenicity of HIV-1 gp41 peptide-containing virosomes.
Bioqual
Rockville, MD
Dr. Mark Lewis
Some of the pre-clinical HIV vaccine studies performed by this contract are:
- Evaluation of immunogenicity and efficacy of DNA/SIV vaccines +/- IL- 12, IL-15, or RANTES DNA delivered by intramuscular electroporation
- Evaluation of the breadth of neutralizing antibodies induced by immunization with HIV-1 R2 gp140 protein in GSK AS01B adjuvant.
University of Washington
Seattle, WA
Dr. David Anderson
HIV vaccine studies conducted by this contract:
- Evaluation of HIV Tat protein vaccine and adenovirus-tat vaccine efficacy in NHP
- Evaluation of replicating adenovirus vector vaccines in the SHIV challenge model
- Determination of protective efficacy of glycan-modified Env vaccine against heterologous SHIV challenge
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