Medical Countermeasures Against Radiological and Nuclear Threats

Centers for Medical Countermeasures against Radiation (CMCR) Publications

2008 | 2007 | 2006

2009

Cummings RJ, Mitra S, Foster TH, Lord EM. Migration of skin dendritic cells in response to ionizing radiation exposure. Radiat Res. 2009 Jun;171(6):687-97.

Kaspler P, Pintilie M, Hill RP. Dynamics of micronuclei in rat skin fibroblasts after X irradiation. Radiat Res. 2009 Jul;172(1):106-13.

Zhang H, Zhang SB, Sun W, Yang S, Zhang M, Wang W, Liu C, Zhang K, Swarts S, Fenton BM, Keng P, Maguire D, Okunieff P, Zhang L. B1 sequence-based real-time quantitative PCR: a sensitive method for direct measurement of mouse plasma DNA levels after gamma irradiation. Int J Radiat Oncol Biol Phys. 2009 Aug 1;74(5):1592-9.

Birmingham A, Selfors LM, Forster T, Wrobel D, Kennedy CJ, Shanks E, Santoyo-Lopez J, Dunican DJ, Long A, Kelleher D, Smith Q, Beijersbergen RL, Ghazal P, Shamu CE. Statistical methods for analysis of high-throughput RNA interference screens. Nat Methods. 2009 Aug;6(8):569-75.

Ivey RG, Subramanian O, Lorentzen TD, Paulovich AG. Antibody-based screen for ionizing radiation-dependent changes in the Mammalian proteome for use in biodosimetry. Radiat Res. 2009 May;171(5):549-61.

Yoon AJ, Shen J, Wu HC, Angelopoulos C, Singer SR, Chen R, Santella RM. Expression of activated checkpoint kinase 2 and histone 2AX in exfoliative oral cells after exposure to ionizing radiation. Radiat Res. 2009 Jun;171(6):771-5.

Tyburski JB, Patterson AD, Krausz KW, Slavík J, Fornace AJ Jr, Gonzalez FJ, Idle JR. Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiat Res. 2009 Jul;172(1):42-57.

Fu Q, Berbée M, Boerma M, Wang J, Schmid HA, Hauer-Jensen M.The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion. Radiat Res. 2009 Jun;171(6):698-707.

Dertinger SD, Bemis JC, Phonethepswath S, Tsai Y, Nowak I, Hyrien O, Palis J, Chen Y. Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age. Mutat Res, 2009 Apr 30; 675: 77-80

Reliene R, Pollard JM, Sobol Z, Trouiller B, Gatti RA, Schiestl RH. N-acetyl cysteine protects against ionizing radiation-induced DNA damage but not against cell killing in yeast and mammals. Mutat Res. 2009 Jun 1;665(1-2):37-43. Epub 2009 Mar 13.

Pollard JM, Reboucas JS, Durazo A, Kos I, Fike F, Panni M, Gralla EB, Valentine JS, Batinic-Haberle I, Gatti RA. Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells. Free Radic Biol Med, 2009 Aug 1; 250-60

Tyurin VA, Tyurina YY, Jung M-Y, Tungekar MA, Wasserloos KJ, Bayir H, Greenberger JS, Kochanek PM, Shvedova AA, Pitt B, Kagan VE. Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues induced by pro-apoptotic and pro-inflammatory stimuli. J Chromatogr B Analyt Technol Biomed Life Sci, 2009 Mar 13

Kagan VE, Bayir HA, Belikova NA, Kapralov O, Tyurina YY, Tyurin VA, Jiang J, Stoyanovsky DA, Wipf P, Kochanek PM, Greenberger JS, Pitt B, Shvedova AA, Borisenko G.Cytochrome c/cardiolipin relations in mitochondria: A kiss of death.Free Radic Biol Med, 2009 Mar 11

Faraji AH, Wipf P. Nanoparticles in cellular drug delivery. Bioorg Med Chem, 2009 Apr 15; 2950-62

Belikova NA, Jiang J, Stoyanovsky DA, Glumac A, Bayir H, Greenberger JS, Kagan VE. Mitochondria-targeted (2-hydroxyamino-vinyl)-triphenyl-phosphonium releases NO(.) and protects mouse embryonic cells against irradiation-induced apoptosis. FEBS Lett, 2009 Jun 18; 583: 1945-50

Sen I, Verdicchio MP, Jung S, Trevino R, Bittner M, Kim S. Context-specific gene regulations in cancer gene expression data. Pac Symp Biocomput. 2009:75-86.

Zhang H, Maguire D, Swarts S, Sun W, Yang S, Wang W, Liu C, Zhang M, Zhang D, Zhang L, Zhang K, Keng P, Zhang L, Okunieff P. Replication of murine mitochondrial DNA following irradiation. Adv Exp Med Biol. 2009;645:43-8.

Ghosh SN, Wu Q, Mäder M, Fish BL, Moulder JE, Jacobs ER, Medhora M, Molthen RC. Vascular injury after whole thoracic x-ray irradiation in the rat. Int J Radiat Oncol Biol Phys. 2009 May 1;74(1):192-9.

Lenarczyk M, Cohen EP, Fish BL, Irving AA, Sharma M, Driscoll CD, Moulder JE. Chronic oxidative stress as a mechanism for radiation nephropathy. Radiat Res. 2009 Feb;171(2):164-72.

Scuric Z, Chan CY, Hafer K, Schiestl RH. Ionizing radiation induces microhomology-mediated end joining in trans in yeast and mammalian cells. Radiat Res. 2009 Apr;171(4):454-63.

Nahas SA, Butch AW, Du L, Gatti RA. Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes. Clin Chem. 2009 Mar;55(3):463-72. Epub 2009 Jan 15.

Mitui M, Nahas SA, Du LT, Yang Z, Lai CH, Nakamura K, Arroyo S, Scott S, Purayidom A, Concannon P, Lavin M, Gatti RA. Functional and computational assessment of missense variants in the ataxia-telangiectasia mutated (ATM) gene: mutations with increased cancer risk. Hum Mutat. 2009 Jan;30(1):12-21.

Piening BD, Wang P, Subramanian A, Paulovich AG. A radiation-derived gene expression signature predicts clinical outcome for breast cancer patients. Radiat Res. 2009 Feb;171(2):141-54.

Zhou H, Hong M, Chai Y, Hei TK. Consequences of cytoplasmic irradiation: studies from microbeam. J Radiat Res (Tokyo). 2009 Mar;50 Suppl A:A59-65.

Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA, Reya T. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. 2009 Apr 9;458(7239):776-9.

Wise-Faberowski L, Warner DS, Spasojevic I, Batinic-Haberle I. Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death. Free Radic Res. 2009 Apr;43(4):329-39.

Kos I, Rebouças JS, DeFreitas-Silva G, Salvemini D, Vujaskovic Z, Dewhirst MW, Spasojević I, Batinić-Haberle I. Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. Free Radic Biol Med. 2009 Jul 1;47(1):72-8.

Kagan VE, Bayir A, Bayir H, Stoyanovsky D, Borisenko GG, Tyurina YY, Wipf P, Atkinson J, Greenberger JS, Chapkin RS, Belikova NA.Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery. Mol Nutr Food Res. 2009 Jan;53(1):104-14.

Greenberger JS.Radioprotection. In Vivo. 2009 Mar-Apr;23(2):323-36.

Faraji AH, Wipf P. Nanoparticles in cellular drug delivery. Bioorg Med Chem. 2009 Apr 15;17(8):2950-62.

2008

Chen Y, Pandya KJ, Feins R, Johnstone DW, Watson T, Smudzin T, Keng PC. Toxicity profile and pharmacokinetic study of a phase I low-dose schedule-dependent radiosensitizing paclitaxel chemoradiation regimen for inoperable non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2008 Jun 1;71(2):407-13.

Cummings RJ, Mitra S, Lord EM, Foster TH. Antibody-labeled fluorescence imaging of dendritic cell populations in vivo. J Biomed Opt. 2008 Jul-Aug;13(4):044041.

Ehlayel M, de Beaucoudrey L, Fike F, Nahas SA, Feinberg J, Casanova JL, Gatti RA. Simultaneous presentation of 2 rare hereditary immunodeficiencies: IL-12 receptor beta1 deficiency and ataxia-telangiectasia. J Allergy Clin Immunol. 2008 Dec;122(6):1217-9.

Kumar S, Kolozsvary A, Kohl R, Lu M, Brown S, Kim JH. Radiation-induced skin injury in the animal model of scleroderma: implications for post-radiotherapy fibrosis. Radiat Oncol. 2008 Nov 24;3:40.

Spasojević I, Chen Y, Noel TJ, Fan P, Zhang L, Rebouças JS, St Clair DK, Batinić-Haberle I. Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice. Free Radic Biol Med. 2008 Oct 1;45(7):943-9.

Rebouças JS, Spasojević I, Batinić-Haberle I. Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes. J Pharm Biomed Anal. 2008 Nov 4;48(3):1046-9.

Borisenko GG, Kapralov AA, Tyurin VA, Maeda A, Stoyanovsky DA, Kagan VE. Molecular design of new inhibitors of peroxidase activity of cytochrome c/cardiolipin complexes: fluorescent oxadiazole-derivatized cardiolipin. Biochemistry. 2008 Dec 23;47(51):13699-710.2008

Epperly MW, Dixon T, Wang H, Schlesselman J, Franicola D, Greenberger JS. Modulation of radiation-induced life shortening by systemic intravenous MnSOD-plasmid liposome gene therapy. Radiat Res. 2008 Oct;170(4):437-43.

Straume T, Amundson SA, Blakely WF, Burns FJ, Chen A, Dainiak N, Franklin S, Leary JA, Loftus DJ, Morgan WF, Pellmar TC, Stolc V, Turteltaub KW, Vaughan AT, Vijayakumar S, Wyrobek AJ. NASA Radiation Biomarker Workshop, September 27-28, 2007. Radiat Res. 2008 Sep;170(3):393-405.

Tyurin VA, Tyurina YY, Kochanek PM, Hamilton R, DeKosky ST, Greenberger JS, Bayir H, Kagan VE. Oxidative lipidomics of programmed cell death. Methods Enzymol. 2008;442:375-93.

Hart JP, McCurdy MR, Ezhil M, Wei W, Khan M, Luo D, Munden RF, Johnson VE, Guerrero TM. Radiation pneumonitis: correlation of toxicity with pulmonary metabolic radiation response. Int J Radiat Oncol Biol Phys. 2008 Jul 15;71(4):967-71.

Brenner DJ. The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction. Semin Radiat Oncol. 2008 Oct;18(4):234-9.

Okunieff P, Chen Y, Maguire DJ, Huser AK. Molecular markers of radiation-related normal tissue toxicity. Cancer Metastasis Rev. 2008 Sep;27(3):363-74.

DeFreitas-Silva G, Rebouças JS, Spasojević I, Benov L, Idemori YM, Batinić-Haberle I. SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself. Arch Biochem Biophys. 2008 Sep 1;477(1):105-12.

Yan S, Brown SL, Kolozsvary A, Freytag SO, Lu M, Kim JH.Mitigation of radiation-induced skin injury by AAV2-mediated MnSOD gene therapy. J Gene Med. 2008 Sep;10(9):1012-8.

Rebouças JS, DeFreitas-Silva G, Spasojević I, Idemori YM, Benov L, Batinić-Haberle I. Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier. Free Radic Biol Med. 2008 Jul 15;45(2):201-10.

Congdon KL, Reya T. Divide and conquer: how asymmetric division shapes cell fate in the hematopoietic system. Curr Opin Immunol. 2008 Jun;20(3):302-7.

Batinic-Haberle I, Benov LT.  An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation. Free Radic Res. 2008 Jul;42(7):618-24.

JH Kim, SL Brown SL, KA Jenrow, S Ryu: Mechanisms of radiation-induced brain toxicity and implications for future clinical trials. J Neuro-Oncol. 87:279-286, 2008

Reboucas, JS, Spasojevic, I, Batinic-Haberle, I. Pure MnTBAP has no SOD activity in aqueous systems, A case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biology. J. Inorg. Biol. Chem. 2008, 13, 289-302.

Jochum C, Beste M, Stone D, Graves SS, Storb R. Development and in vitro characterization of canine CD40-lg. Vet Immunol Immunopathol 123: 260-265, 2008.

Huang Z, Jiang J, Tyurin VA, Zhao Q, Mnuskin A, Ren J, Belikova NA, Feng W, Kurnikov IV, Kagan VE.Cardiolipin deficiency leads to decreased cardiolipin peroxidation and increased resistance of cells to apoptosis. Free Radic Biol Med. 2008 Jun 1;44(11):1935-44.

Bayir H, Kagan VE. Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis - there is nothing more practical than a good theory. Crit Care. 2008; 12(1):206.

Tyburski JB, Patterson AD, Krausz KW, Slavík J, Fornace AJ, Gonzalez FJ, Idle JR. Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice. Radiat Res. 2008 Jul;170(1):1-14.

Paul S, Amundson SA. Development of gene expression signatures for practical radiation biodosimetry. Int J Radiat Oncol Biol Phys. 2008 Jul 15;71(4):1236-1244.

Zhang X, Epperly MW, Kay MA, Smith T, Franicola D, Greenberger B, Komanduri P, Greenberger JS. Radioprotection In Vitro and In Vivo by Mini Circle Plasmid Containing the Human Manganese Superoxide Dismutase (MnSOD) Transgene. Hum Gene Ther. 2008 Aug;19(8):820-6.

Congdon KL, Voermans C, Ferguson EC, DiMascio LN, Uqoezwa M, Zhao C, Reya T. Activation of Wnt signaling in hematopoietic regeneration. Stem Cells. 2008 May;26(5):1202-10.

Zhang R, Ghosh S, Zhu D, North P, Fish B, Morrow N, Lowry T, Nanchal R, Jacobs E, Moulder J, Medhora M. Structural and functional alterations in the rat lung following whole thoracic irradiation with moderate doses: Injury and recovery. Int J Radiat Biol. 2008 June;84(6):487–497. 

Ma X, Chen C, Krausz KW, Idle JR, Gonzalez FJ. A metabolomic perspective of melatonin metabolism in the mouse. Endocrinology. 2008 Apr;149(4):1869-79.

Meadows SK, Dressman HK, Muramoto GG, Himburg H, Salter A, Wei Z, Ginsburg G, Chao NJ, Nevins JR, Chute JP. Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS ONE. 2008 Apr 2;3(4):e1912.

Rebouças JS, Spasojević I, Tjahjono DH, Richaud A, Méndez F, Benov L, Batinić-Haberle I. Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: the effect of charge distribution. Dalton Trans. 2008 Mar 7;(9):1233-42.

Blakaj A, Lin H. Piecing together the mosaic of early mammalian development through microRNAs. J Biol Chem. 2008 Apr 11;283(15):9505-8.

Gauter-Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Batinic-Haberle I, Vujaskovic Z. Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. Free Radic Biol Med. 2008 Mar 15;44(6):982-9.

Lupu M, Gooley T, Zellmer E, Graves SS, Storb R. Principles of peripheral blood mononuclear cell apheresis in a preclinical canine model of hematopoietic cell transplantation. J Vet Intern Med. 2008 Jan-Feb;22(1):74-82.

Stoyanovsky DA, Vlasova II, Belikova NA, Kapralov A, Tyurin V, Kagan VE. Activation of NO donors in mitochondria: peroxidase metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by cytochrome c releases NO and protects cells against apoptosis. FEBS Lett. 2008 Mar 5;582(5):725-8.

Hafer K, Iwamoto KS, Schiestl RH. Refinement of the dichlorofluorescein assay for flow cytometric measurement of reactive oxygen species in irradiated and bystander cell populations. Radiat Res. 2008 Apr;169(4):460-8.

Hafer K, Konishi T, Schiestl RH. Radiation-induced long-lived extracellular radicals do not contribute to measurement of intracellular reactive oxygen species using the dichlorofluorescein method. Radiat Res. 2008 Apr;169(4):469-73.

Brown SL, Kolozsvary A, Liu J, Ryu S, Kim JH. Histone deacetylase inhibitors protect against and mitigate the lethality of total-body irradiation in mice. Radiat Res. 2008 Apr;169(4):474-8.

Sun W, Wang W, Kim J, Keng P, Yang S, Zhang H, Liu C, Okunieff P, Zhang L. Anti-cancer effect of resveratrol is associated with induction of apoptosis via a mitochondrial pathway alignment. Adv Exp Med Biol. 2008;614:179-86.

Okunieff P, Swarts S, Keng P, Sun W, Wang W, Kim J, Yang S, Zhang H, Liu C, Williams JP, Huser AK, Zhang L. Antioxidants reduce consequences of radiation exposure. Adv Exp Med Biol. 2008;614:165-78.

Patterson AD, Li H, Eichler GS, Krausz KW, Weinstein JN, Fornace AJ Jr, Gonzalez FJ, Idle JR. UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. Anal Chem. 2008 Feb 1;80(3):665-74.

Tyurina YY, Tyurin VA, Epperly MW, Greenberger JS, Kagan VE. Oxidative lipidomics of gamma-irradiation-induced intestinal injury. Free Radic Biol Med. 2008 Feb 1;44(3):299-314.

Jiang J, Huang Z, Zhao Q, Feng W, Belikova NA, Kagan VE. Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis. Biochem Biophys Res Commun. 2008 Mar 28;368(1):145-50.

Cavalieri S, Funaro A, Pappi P, Migone N, Gatti RA, Brusco A. Large Genomic mutations within the ATM gene detected by MLPA, including a duplication of 41 kb from exon 4 to 20. Ann Hum Genet. 2008 Jan;72(Pt 1):10-8.

Jiang J, Belikova NA, Hoye AT, Zhao Q, Epperly MW, Greenberger JS, Wipf P, Kagan VE. A mitochondria-targeted nitroxide/hemigramicidin s conjugate protects mouse embryonic cells against gamma irradiation. Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):816-25.  

2007

Lahaye, D, Muthukumaran, K, Gryko, D, Hung, C-H, Reboucas, JS, Spasojevic, I, Batinic-Haberle, I, Lindsey, JS. Design and synthesis of manganese porphyrins with tailored lipophilicity: Investigation of redox properties and superoxide dismutase activity. Biorg. Med. Chem. 2007, 15, 7066-7086.

Hill RP, Kaspler P,  Griffin AM, O'Sullivan B, Catton C, Alasti H, Abbas A, Heydarian M, Ferguson P, JS Wunder, Bell RS. Studies of the in vivo radiosensitivity of human skin fibroblasts. Radiother Oncol. 2007 Jul; 84(1): 75-83.

Dertinger SD, Tsai Y, Nowak I, Hyrien O, Sun H, Bemis JC, Torous DK, Keng P, Palis J, Chen Y. Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry. Mutat Res 634:119-125, 2007.

Ambrose M, Goldstine JV, Gatti RA. Intrinsic mitochondria! dysfunction in ATM-deficient lymphoblastoid cells. Hum Mol Genet 16: 2154-64, 2007.

Zhao C, Blum J, Chen A, Kwon HY, Jung SH, Cook JM, Lagoo A, Reya T. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell. 2007 Dec;12(6):528-41.

Moore CB, Medina MA, van Deventer HW, O'Connor BP, Cameron S, Taxman DJ, Maile R, Ting JP, Cairns BA. Downregulation of immune signaling genes in patients with large surface burn injury. J Burn Care Res. 2007 Nov-Dec;28(6):879-87.

Kapralov AA, Kurnikov IV, Vlasova II, Belikova NA, Tyurin VA, Basova LV, Zhao Q, Tyurina YY, Jiang J, Bayir H, Vladimirov YA, Kagan VE. The hierarchy of structural transitions induced in cytochrome c by anionic phospholipids determines its peroxidase activation and selective peroxidation during apoptosis in cells. Biochemistry. 2007 Dec 11;46(49):14232-44.

Romanyukha A, Trompier F, Leblanc B, Calas C, Clairand I, Mitchell CA, Smirniotopoulos JG, Swartz HM. EPR dosimetry in chemically treated fingernails. Radiat Meas. 2007 42(6-7):1110-1113.

Trompier F, Kornak L, Calas C, Romanyukha A, Leblanc B, Mitchell CA, Swartz HM, Clairand I. Protocol for emergency EPR dosimetry in fingernails. Radiat Meas. 2007 42(6-7):1085-1088.

Brenner DJ, Shuryak I, Russo S, Sachs RK. Reducing second breast cancers: a potential role for prophylactic mammary irradiation. J Clin Oncol. 2007 Nov 1;25(31):4868-72.

Kim S, Sen I, Bittner M. Mining molecular contexts of cancer via in-silico conditioning. Comput Syst Bioinformatics Conf. 2007;6:169-79.

Fung H, Liu P, Demple B. ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis. Mol Cell Biol. 2007 Dec;27(24):8834-47. Epub 2007 Oct 15.

Narciso L, Fortini P, Pajalunga D, Franchitto A, Liu P, Degan P, Frechet M, Demple B, Crescenzi M, Dogliotti E. Terminally differentiated muscle cells are defective in base excision DNA repair and hypersensitive to oxygen injury. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17010-5. Epub 2007 Oct 16.

Belikova NA, Jiang J, Tyurina YY, Zhao Q, Epperly MW, Greenberger J, Kagan VE. Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis. Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):176-86.

Hontzeas N, Hafer K, Schiestl RH. Development of a microtiter plate version of the yeast DEL assay amenable to high-throughput toxicity screening of chemical libraries. Mutat Res. 2007 Dec 1;634(1-2):228-34. Epub 2007 Jul 10.

Hill RP, Perris R. "Destemming" cancer stem cells. J Natl Cancer Inst. 2007 Oct 3;99(19):1435-40. Epub 2007 Sep 25. Review.

Brenner DJ, Hall EJ. Computed tomography--an increasing source of radiation exposure. N Engl J Med. 2007 Nov 29;357(22):2277-84. Review.

Romanyukha A, Mitchell CA, Schauer DA, Romanyukha L, Swartz HM. Q-band EPR biodosimetry in tooth enamel microsamples: feasibility test and comparison with x-band. Health Phys. 2007 Dec;93(6):631-5.

Kohl RR, Kolozsvary A, Brown SL, Zhu G, Kim JH.  Differential radiation effect in tumor and normal tissue after treatment with ramipril, an angiotensin-converting enzyme inhibitor. Radiat Res. 2007 Oct;168(4):440-5.

Zabrouskov V, Whitelegge JP. Increased coverage in the transmembrane domain with activated-ion electron capture dissociation for top-down Fourier-transform mass spectrometry of integral membrane proteins. J Proteome Res. 2007 Jun;6(6):2205-10.

Landmark H, Nahas SA, Aaroe J, Gatti R, Borresen-Dale AL, Rodningen OK. Transcriptional response to ionizing radiation in human radiation sensitive cell lines. Radiother Oncol. 2007 Jun;83(3):256-60.

Lavin MF, Gueven N, Bottle S, Gatti RA. Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia. Br Med Bull. 2007;81-82:129-47.

Hafer K, Iwamoto KK, Scuric Z, Schiestl RH. Adaptive response to gamma radiation in mammalian cells proficient and deficient in components of nucleotide excision repair. Radiat Res. 2007 Aug;168(2):168-74.

Otterson MF. Effects of radiation upon gastrointestinal motility. World J Gastroenterol. 2007 May 21;13(19):2684-92.

Bristow RG, Ozcelik H, Jalali F, Chan N, Vesprini D. Homologous recombination and prostate cancer: a model for novel DNA repair targets and therapies. Radiother Oncol. 2007 Jun;83(3):220-30.

Su Y, Yang S, Xiao Z, Wang W, Okunieff P, Zhang L. Triptolide alters mitochondrial functions. Adv Exp Med Biol. 2007;599:139-46.

Venkataraman GM, Stroup P, Graves SS, Storb R. An improved method for dog leukocyte antigen 88 typing and two new major histocompatibility complex class I alleles, DLA-88*01101 and DLA-88*01201. Tissue Antigens. 2007 Jul;70(1):53-7.

Fernandes ND, Sun Y, Price BD. Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells. J Biol Chem. 2007 Jun 1;282(22):16577-84.

Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau LA, Shimamura A, D'Andrea AD. Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest. 2007 May;117(5):1440-9.

Spasojevic I, Chen Y, Noel TJ, Yu Y, Cole MP, Zhang L, Zhao Y, St Clair DK, Batinic-Haberle I. Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria. Free Radic Biol Med. 2007 Apr 15;42(8):1193-200.

Zhen Y, Krausz KW, Chen C, Idle JR, Gonzalez FJ. Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation. Mol Endocrinol. 2007 Sep;21(9):2136-51.

Bayir H, Tyurin VA, Tyurina YY, Viner R, Ritov V, Amoscato AA, Zhao Q, Zhang XJ, Janesko-Feldman KL, Alexander H, Basova LV, Clark RS, Kochanek PM, Kagan VE. Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis. Ann Neurol. 2007 Aug 8;62(2):154-69.

Al-Mutairi DA, Craik JD, Batinic-Haberle I, Benov LT. Inactivation of metabolic enzymes by photo-treatment with zinc meta N-methylpyridylporphyrin. Biochim Biophys Acta. 2007 Jun 23 [Epub ahead of print].

Jiang J, Kurnikov I, Belikova NA, Xiao J, Zhao Q, Amoscato AA, Braslau R, Studer A, Fink MP, Greenberger JS, Wipf P, Kagan VE. Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides. J Pharmacol Exp Ther. 2007 Mar;320(3):1050-60.

Tyurina YY, Basova LV, Konduru NV, Tyurin VA, Potapovich AI, Cai P, Bayir H, Stoyanovsky D, Pitt BR, Shvedova AA, Fadeel B, Kagan VE. Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: implications for the resolution of inflammation. J Biol Chem. 2007 Mar 16;282(11):8498-509.

Basova LV, Kurnikov IV, Wang L, Ritov VB, Belikova NA, Vlasova II, Pacheco AA, Winnica DE, Peterson J, Bayir H, Waldeck DH, Kagan VE. Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity. Biochemistry. 2007 Mar 20;46(11):3423-34.

Tyurin VA, Tyurina YY, Osipov AN, Belikova NA, Basova LV, Kapralov AA, Bayir H, Kagan VE. Interactions of cardiolipin and lyso-cardiolipins with cytochrome c and tBid: conflict or assistance in apoptosis. Cell Death Differ. 2007 Apr;14(4):872-5.

Ma X, Shah Y, Cheung C, Guo G, Feigenbaum L, Krausz K, Idle J, Gonzalez F. The PREgnane X Receptor Gene-Humanized Mouse: A model for Investigator Drug-Drug Interactions Mediated by Cytochromes P450 3A. Drug Metabolism and Disposition 2007; 35(2): 194-200.

Jochum C, Beste M, Zellmer E, Graves SS, Storb R. CD154 blockade and donor-specific transfusions in DLA-identical marrow transplantation in dogs conditioned with 1-Gy total body irradiation. Biol Blood Marrow Transplant. 2007 Feb;13(2):164-71.

Parmar K, Mauch P, Vergillo JA, Sackstein R, Down J . Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. PNAS March 27, 2007; 104(13):5431-36.

Stegmeier F, Sowa M, Nalepa G, Gygi S, Harper W, Elledge S. The tumor suppressor CYLD regulates entry into mitosis. PNAS May 22, 2007; 104(21):8869-74.

Al-Mutairi DA, Craik JD, Batinic-Haberle I, Benov LT. Induction of oxidative cell damage by photo-treatment with zinc meta N-methylpyridylporphyrin. Free Radic Res. 2007 Jan;41(1):89-96.

Brush J, Lipnick SL, Phillips T, Sitko J, McDonald JT, McBride WH. Molecular mechanisms of late normal tissue injury. Semin Radiat Oncol. 2007; 17(2):121-30.

Smogorzewska A, Matsuoka S, Vinciguerra P, et al. Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell. 2007; 129:289-301.

Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science. 2007;316(5828):1194-8.

Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007;316(5828):1160-6.

Chao NJ. Accidental or intentional exposure to ionizing radiation: Biodosimetry and treatment options. Exp Hematol. 2007; 35(4 Suppl 1):24-7.

Dressman HK, Muramoto GG, Chao NJ, Meadows S, Marshall D, et al. Gene expression signatures that predict radiation exposure in mice and humans. PLoS Med. 2007; 4(4):e106.

Chute JP, Muramoto GG, Salter AB, Meadows SK, Rickman DW, Chen B, Himburg HA, Chao NJ. Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. Blood. 2007; 109(6):2365-72.

Dertinger SD, Miller RK, Brewer K, Smudzin T, Torous DK, Roberts DJ, Avlasevich SL, Bryce SM, Sugunan S, Chen Y. Automated human blood micronucleated reticulocyte measurements for rapid assessment of chromosomal damage. Mutat Res: Genet Toxicol Environ Mutagen. 2007; 626(1-2):111-9.

Moulder JE, Cohen EP. Renal dysfunction after total body irradiation: dose-effect relationship: in regard to Kal and van Kempen-Harteveld. Int J Radiat Oncol Biol Phys. 2007; 67(1):319; author reply 319-20.
 

2006

Clements CM, McNally RS, Conti BJ, Mak TW, Ting JP. DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15091-6.

Al-Mutairi DA, Craik JD, Batinic-Haberle I, Benov LT. Photosensitizing action of isomeric zinc N-methylpyridylporphyrins in human carcinoma cells. Free Radic Res. 2006 May;40(5):477-83. 

Haga K, Lemp NA, Logg CR, Nagashima J, Faure-Kumar E, Gomez GG, Kruse CA, Mendez R, Stripecke R, Kasahara N, Cicciarelli JC. Permanent, lowered HLA class I expression using lentivirus vectors with shRNA constructs: Averting cytotoxicity by alloreactive T lymphocytes. Transplant Proc. 2006 Dec;38(10):3184-8.

Cavalieri S, Funaro A, Porcedda P, Turinetto V, Migone N, Gatti RA, Brusco A. ATM mutations in Italian families with ataxia telangiectasia include two distinct large genomic deletions. Hum Mutat. 2006 Oct;27(10):1061.

Lakatos HF, Burgess HA, Thatcher TH, Redonnet MR, Hernady E, Williams JP, Sime PJ. Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation. Exp Lung Res. 2006 May;32(5):181-99.

Batinic-Haberle I, Spasojevic I, Stevens RD, Bondurant B, Okado-Matsumoto A, Fridovich I, Vujaskovic Z, Dewhirst MW. New PEG-ylated Mn(III) porphyrins approaching catalytic activity of SOD enzyme. Dalton Trans. 2006 Jan 28;(4):617-24.

Zhang D, Zaugg K,Mak T, Elledge S. A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell. 126. August 11, 2006: 529-542.

Hafer K, Scuric Z, Iwamoto KS, Schiestl RH. Point-source irradiation with eccentric rotation causes inhomogeneous dose distribution. Radiat Res. 2006; 165(5):616-20.

Shuryak I, Sachs RK, Hlatky L, Little MP, Hahnfeldt P, Brenner DJ. Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks. J Natl Cancer Inst. 2006; 98(24):1794-806.

Mielcarek M, Georges GE, Storb R. Denileukin diftitox as prophylaxis against graft-versus-host disease in the canine hematopoietic cell transplantation model. Biol Blood Marrow Transplant. 2006; 12(9):899-904.

Greenberger JS. Could gene therapy prevent the effects of irradiation exposure? Pharmacogenomics. 2006; 7(8):1141-5.

Kagan VE, Tyurina YY, Bayir H, Chu CT, Kapralov AV, Vlasova II, Belikova NA, Tyurin VA, Amoscato A, Epperly M, Greenberger J, DeKosky S, Shvedova AA, Jiang J. The "pro-apoptotic genies" get out of mitochondria: oxidative lipidomics and redox activity of cytochrome c/Cardiolipin complexes. Chem Biol Interactions. 2006; 163(1-2):15-28.

Belikova NA, Vladimirov YA, Osipov AN, Kapralov AA, Tyurin VA, Potapovich MW, Basova LV, Peterson J, Kurnikov IV, Kagan VE. Peroxidase activity and structural transitions of cytochrome c bound to cardiolipin-containing membranes. Biochemistry. 2006; 45(15):4998-5009.

Vlasova II, Tyurin VA, Kapralov AA, Kurnikov IV, Osipov AN, Potapovich MV, Stoyanovsky DA, Kagan VE. Nitric oxide inhibits peroxidase activity of cytochrome c.cardiolipin complex and blocks cardiolipin oxidation. J Biol Chem. 2006; 281(21):14554-62.

Tyurina YY, Kini V, Tyurin VA, Vlasova II, Jiang J, Kapralov AA, Belikova NA, Yalowich JC, Kurnikov IV, Kagan VE. Mechanisms of cardiolipin oxidation by cytochrome c: relevance to pro- and anti-apoptotic functions of etoposide. Mol Pharmacol. 2006; 70(2):706-17.

Bayir H, Fadeel B, Palladino MJ, Witasp E, Kurnikov IV, Tyurina YY, Tyurin VA, Amoscato AA, Jiang J, Kochanek PM, DeKosky ST, Greenberger JS, Shvedova AA, Kagan VE. Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria. Biochim Biophys Acta. 2006; 1757(5-6):648-59.

Z Xiao, Y Su, S Yang, L Yin, W Wang, Y Yi, BM Fenton, L Zhang, P Okunieff. Protective effect of Esculentoside-A on radiation-induced dermatitis and fibrosis. J Radiat Oncol Biol Phys. 2006; 65(3):882-9.

P Okunieff, J Xu, D Hu, W Liu, L Zhang, G Morrow, A Pentland, J Ryan, I Ding. Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines. Int J Radiat Oncol Biol Phys. 2006; 65(3):890-898.

Frank Pajonk F, Anja Riedisser A, Henke M, McBride WH, Fiebich B. The effects of tea extracts on proinflammatory signaling. BMC Med. 2006; 4:28.

Liu W-C, Wang S-C, Tsai M-L, Chen M-C, Wang Y-C, Hong J-H, McBride WH, Chiang, C-S. Protection against Radiation-Induced Bone Marrow and Intestinal Injuries by Cordyceps sinensis, a Chinese Herbal Medicine. Radiat Res. 2006; 166:900–907.

Goldstine JV, Nahas S, Gamo K, Gartler SM, Hansen RS, Roelfsema JH, Gatti RA, Marahrens Y. Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with IGF syndrome without downstream kinase activity. DNA Repair. 2006; 5:432-43.

OA Hatoum, MF Otterson, D Kopelman, H Miura, I Sukhotnik, BT Larsen, RM Selle, JE Moulder, DD Gutterman.  Radiation Induces Endothelial Dysfunction in Murine Intestinal Arterioles via Enhanced Production of Reactive Oxygen Species. Arterioscler Thromb Vasc Biol. 2006; 26:287-294.

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